| 1 | Sun 1 Aug 2021 | 6 4-2 v RostovRostov 2-4 Zenit St Petersburg | Russian Premier League |
| 2 | Sat 7 Aug 2021 | 63-2 v FK KrasnodarZenit St Petersburg 3-2 FK Krasnodar | Russian Premier League |
| 3 | Sun 15 Aug 2021 | 61-1 v Lokomotiv MoscowLokomotiv Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 4 | Sat 21 Aug 2021 | 61-1 v UfaUfa 1-1 Zenit St Petersburg | Russian Premier League |
| 5 | Thu 26 Aug 2021 | 61-0 v CSKA MoscowZenit St Petersburg 1-0 CSKA Moscow | Russian Premier League |
| 6 | Sat 16 Oct 2021 | 61-2 v Arsenal TulaArsenal Tula 2-1 Zenit St Petersburg | Russian Premier League |
| 7 | Wed 20 Oct 2021 | 60-1 v JuventusZenit St Petersburg 0-1 Juventus | UEFA Champions League Group H |
| 8 | Sun 24 Oct 2021 | 67-1 v Spartak MoscowZenit St Petersburg 7-1 Spartak Moscow | Russian Premier League |
| 9 | Fri 29 Oct 2021 | 6 4-1 v Dinamo MoscowZenit St Petersburg 4-1 Dinamo Moscow | Russian Premier League |
| 10 | Tue 2 Nov 2021 | 6 2-4 v JuventusJuventus 4-2 Zenit St Petersburg | UEFA Champions League Group H |
| 11 | Sun 7 Nov 2021 | 60-0 v UralUral 0-0 Zenit St Petersburg | Russian Premier League |
| 12 | Fri 19 Nov 2021 | 65-1 v Nizhny NovgorodZenit St Petersburg 5-1 Nizhny Novgorod | Russian Premier League |
| 13 | Tue 23 Nov 2021 | 61-1 v Malmö FFMalmö FF 1-1 Zenit St Petersburg | UEFA Champions League Group H |
| 14 | Sun 28 Nov 2021 | 62-0 v CSKA MoscowCSKA Moscow 0-2 Zenit St Petersburg | Russian Premier League |
| 15 | Fri 3 Dec 2021 | 62-2 v RostovZenit St Petersburg 2-2 Rostov | Russian Premier League |
| 16 | Wed 8 Dec 2021 | 6 3-3 v ChelseaZenit St Petersburg 3-3 Chelsea | UEFA Champions League Group H |
| 17 | Sun 12 Dec 2021 | 61-1 v Dinamo MoscowDinamo Moscow 1-1 Zenit St Petersburg | Russian Premier League |
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