| 1 | Sun 6 Feb 2022 | 63-1 v RKC WaalwijkWillem II 3-1 RKC Waalwijk | Dutch Eredivisie |
| 2 | Sun 13 Feb 2022 | 60-1 v Sparta RotterdamSparta Rotterdam 1-0 Willem II | Dutch Eredivisie |
| 3 | Sat 19 Feb 2022 | 60-1 v AjaxWillem II 0-1 Ajax | Dutch Eredivisie |
| 4 | Sat 26 Feb 2022 | 60-1 v FC GroningenFC Groningen 1-0 Willem II | Dutch Eredivisie |
| 5 | Sat 5 Mar 2022 | 60-0 v sc HeerenveenWillem II 0-0 sc Heerenveen | Dutch Eredivisie |
| 6 | Sun 13 Mar 2022 | 60-1 v Fortuna SittardFortuna Sittard 1-0 Willem II | Dutch Eredivisie |
| 7 | Sun 20 Mar 2022 | 62-2 v AZ AlkmaarWillem II 2-2 AZ Alkmaar | Dutch Eredivisie |
| 8 | Sat 2 Apr 2022 | 60-2 v FeyenoordFeyenoord 2-0 Willem II | Dutch Eredivisie |
| 9 | Fri 8 Apr 2022 | 60-4 v Go Ahead EaglesGo Ahead Eagles 4-0 Willem II | Dutch Eredivisie |
| 10 | Sun 24 Apr 2022 | 61-0 v VitesseWillem II 1-0 Vitesse | Dutch Eredivisie |
| 11 | Sun 1 May 2022 | 62-4 v PSV EindhovenPSV Eindhoven 4-2 Willem II | Dutch Eredivisie |
| 12 | Sat 7 May 2022 | 62-0 v Heracles AlmeloWillem II 2-0 Heracles Almelo | Dutch Eredivisie |
| 13 | Sun 15 May 2022 | 63-0 v FC UtrechtWillem II 3-0 FC Utrecht | Dutch Eredivisie |
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