| 1 | Thu 26 Aug 2021 | 362-1 v RSC AnderlechtVitesse 2-1 RSC Anderlecht | UEFA Europa Conference League |
| 2 | Sun 29 Aug 2021 | 360-5 v AjaxAjax 5-0 Vitesse | Dutch Eredivisie |
| 3 | Sun 12 Sep 2021 | 362-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 4 | Thu 16 Sep 2021 | 362-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 5 | Sun 19 Sep 2021 | 361-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 6 | Wed 22 Sep 2021 | 361-0 v FC GroningenFC Groningen 0-1 Vitesse | Dutch Eredivisie |
| 7 | Sun 3 Oct 2021 | 362-1 v FeyenoordVitesse 2-1 Feyenoord | Dutch Eredivisie |
| 8 | Sun 17 Oct 2021 | 361-0 v NEC NijmegenNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 9 | Sun 7 Nov 2021 | 362-1 v FC UtrechtVitesse 2-1 FC Utrecht | Dutch Eredivisie |
| 10 | Sun 28 Nov 2021 | 360-0 v AZ AlkmaarVitesse 0-0 AZ Alkmaar | Dutch Eredivisie |
| 11 | Sun 12 Dec 2021 | 362-1 v Heracles AlmeloVitesse 2-1 Heracles Almelo | Dutch Eredivisie |
| 12 | Sat 18 Dec 2021 | 362-2 v Sparta RotterdamSparta Rotterdam 2-2 Vitesse | Dutch Eredivisie |
| 13 | Tue 21 Dec 2021 | 36 1-0 v PEC ZwolleVitesse 1-0 PEC Zwolle | Dutch Eredivisie |
| 14 | Sat 15 Jan 2022 | 361-0 v FeyenoordFeyenoord 0-1 Vitesse | Dutch Eredivisie |
| 15 | Sat 22 Jan 2022 | 361-3 v FC GroningenVitesse 1-3 FC Groningen | Dutch Eredivisie |
| 16 | Sat 12 Feb 2022 | 360-5 v PSV EindhovenVitesse 0-5 PSV Eindhoven | Dutch Eredivisie |
| 17 | Thu 24 Feb 2022 | 362-0 v Rapid ViennaVitesse 2-0 Rapid Vienna | UEFA Europa Conference League |
| 18 | Sun 27 Feb 2022 | 364-1 v NEC NijmegenVitesse 4-1 NEC Nijmegen | Dutch Eredivisie |
| 19 | Sun 1 May 2022 | 362-1 v Go Ahead EaglesGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 20 | Sun 8 May 2022 | 361-2 v sc HeerenveenVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 21 | Wed 11 May 2022 | 362-1 v Fortuna SittardFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 22 | Sun 15 May 2022 | 362-2 v AjaxVitesse 2-2 Ajax | Dutch Eredivisie |
| 23 | Thu 19 May 2022 | 361-3 v FC UtrechtFC Utrecht 3-1 Vitesse | Dutch Eredivisie Play-off |
| 24 | Sun 22 May 2022 | 363-0 v FC UtrechtVitesse 3-0 FC Utrecht | Dutch Eredivisie Play-off |
| 25 | Thu 26 May 2022 | 362-1 v AZ AlkmaarVitesse 2-1 AZ Alkmaar | Dutch Eredivisie Play-off |
| 26 | Sun 29 May 2022 | 361-6 v AZ AlkmaarAZ Alkmaar 6-1 Vitesse | Dutch Eredivisie Play-off |
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