| 1 | Sun 15 Aug 2021 | 91-0 v PEC ZwollePEC Zwolle 0-1 Vitesse | Dutch Eredivisie |
| 2 | Thu 26 Aug 2021 | 92-1 v RSC AnderlechtVitesse 2-1 RSC Anderlecht | UEFA Europa Conference League |
| 3 | Sun 12 Sep 2021 | 92-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 4 | Thu 16 Sep 2021 | 92-0 v Mura Murska SobotaMura Murska Sobota 0-2 Vitesse | UEFA Europa Conference League |
| 5 | Sun 19 Sep 2021 | 91-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 6 | Wed 22 Sep 2021 | 91-0 v FC GroningenFC Groningen 0-1 Vitesse | Dutch Eredivisie |
| 7 | Sat 25 Sep 2021 | 91-1 v Fortuna SittardVitesse 1-1 Fortuna Sittard | Dutch Eredivisie |
| 8 | Thu 30 Sep 2021 | 91-2 v RennesVitesse 1-2 Rennes | UEFA Europa Conference League |
| 9 | Sun 3 Oct 2021 | 92-1 v FeyenoordVitesse 2-1 Feyenoord | Dutch Eredivisie |
| 10 | Sun 17 Oct 2021 | 91-0 v NEC NijmegenNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 11 | Thu 21 Oct 2021 | 91-0 v Tottenham HotspurVitesse 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 12 | Sun 24 Oct 2021 | 9 1-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 13 | Sat 30 Oct 2021 | 92-1 v sc Heerenveensc Heerenveen 1-2 Vitesse | Dutch Eredivisie |
| 14 | Thu 4 Nov 2021 | 92-3 v Tottenham HotspurTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 15 | Sun 7 Nov 2021 | 92-1 v FC UtrechtVitesse 2-1 FC Utrecht | Dutch Eredivisie |
| 16 | Sat 20 Nov 2021 | 90-2 v PSV EindhovenPSV Eindhoven 2-0 Vitesse | Dutch Eredivisie |
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