| 1 | Sun 15 Aug 2021 | 391-0 v PEC ZwollePEC Zwolle 0-1 Vitesse | Dutch Eredivisie |
| 2 | Sun 22 Aug 2021 | 390-3 v Willem IIVitesse 0-3 Willem II | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 390-5 v AjaxAjax 5-0 Vitesse | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 392-1 v RKC WaalwijkRKC Waalwijk 1-2 Vitesse | Dutch Eredivisie |
| 5 | Sun 19 Sep 2021 | 391-4 v FC TwenteVitesse 1-4 FC Twente | Dutch Eredivisie |
| 6 | Sun 24 Oct 2021 | 391-2 v Go Ahead EaglesVitesse 1-2 Go Ahead Eagles | Dutch Eredivisie |
| 7 | Sat 22 Jan 2022 | 391-3 v FC GroningenVitesse 1-3 FC Groningen | Dutch Eredivisie |
| 8 | Sun 13 Mar 2022 | 390-0 v Heracles AlmeloHeracles Almelo 0-0 Vitesse | Dutch Eredivisie |
| 9 | Sun 20 Mar 2022 | 391-2 v RKC WaalwijkVitesse 1-2 RKC Waalwijk | Dutch Eredivisie |
| 10 | Sun 1 May 2022 | 392-1 v Go Ahead EaglesGo Ahead Eagles 1-2 Vitesse | Dutch Eredivisie |
| 11 | Sun 8 May 2022 | 391-2 v sc HeerenveenVitesse 1-2 sc Heerenveen | Dutch Eredivisie |
| 12 | Wed 11 May 2022 | 392-1 v Fortuna SittardFortuna Sittard 1-2 Vitesse | Dutch Eredivisie |
| 13 | Sun 15 May 2022 | 392-2 v AjaxVitesse 2-2 Ajax | Dutch Eredivisie |
| 14 | Thu 19 May 2022 | 391-3 v FC UtrechtFC Utrecht 3-1 Vitesse | Dutch Eredivisie Play-off |
| 15 | Sun 29 May 2022 | 391-6 v AZ AlkmaarAZ Alkmaar 6-1 Vitesse | Dutch Eredivisie Play-off |
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