| 1 | Sat 14 Aug 2021 | 91-0 v VfL BochumVfL Wolfsburg 1-0 VfL Bochum | German Bundesliga |
| 2 | Sat 21 Aug 2021 | 92-1 v Hertha BerlinHertha Berlin 1-2 VfL Wolfsburg | German Bundesliga |
| 3 | Sun 29 Aug 2021 | 91-0 v RB LeipzigVfL Wolfsburg 1-0 RB Leipzig | German Bundesliga |
| 4 | Sat 11 Sep 2021 | 9 2-0 v Greuther FürthGreuther Fürth 0-2 VfL Wolfsburg | German Bundesliga |
| 5 | Tue 14 Sep 2021 | 90-0 v LilleLille 0-0 VfL Wolfsburg | UEFA Champions League Group G |
| 6 | Sun 19 Sep 2021 | 91-1 v Eintracht FrankfurtVfL Wolfsburg 1-1 Eintracht Frankfurt | German Bundesliga |
| 7 | Sat 25 Sep 2021 | 91-3 v 1899 Hoffenheim1899 Hoffenheim 3-1 VfL Wolfsburg | German Bundesliga |
| 8 | Wed 29 Sep 2021 | 9 1-1 v SevillaVfL Wolfsburg 1-1 Sevilla | UEFA Champions League Group G |
| 9 | Sat 2 Oct 2021 | 9 1-3 v Borussia MönchengladbachVfL Wolfsburg 1-3 Borussia Mönchengladbach | German Bundesliga |
| 10 | Sat 16 Oct 2021 | 90-2 v 1. FC Union Berlin1. FC Union Berlin 2-0 VfL Wolfsburg | German Bundesliga |
| 11 | Tue 2 Nov 2021 | 9 2-1 v SV Red Bull SalzburgVfL Wolfsburg 2-1 SV Red Bull Salzburg | UEFA Champions League Group G |
| 12 | Sat 6 Nov 2021 | 91-0 v FC AugsburgVfL Wolfsburg 1-0 FC Augsburg | German Bundesliga |
| 13 | Sat 20 Nov 2021 | 92-2 v Arminia BielefeldArminia Bielefeld 2-2 VfL Wolfsburg | German Bundesliga |
| 14 | Tue 23 Nov 2021 | 90-2 v SevillaSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 15 | Sat 27 Nov 2021 | 91-3 v Borussia DortmundVfL Wolfsburg 1-3 Borussia Dortmund | German Bundesliga |
| 16 | Sat 4 Dec 2021 | 90-3 v Mainz 05Mainz 05 3-0 VfL Wolfsburg | German Bundesliga |
| 17 | Wed 8 Dec 2021 | 91-3 v LilleVfL Wolfsburg 1-3 Lille | UEFA Champions League Group G |
| 18 | Sat 11 Dec 2021 | 90-2 v VfB StuttgartVfL Wolfsburg 0-2 VfB Stuttgart | German Bundesliga |
| 19 | Tue 14 Dec 2021 | 92-3 v 1. FC KölnVfL Wolfsburg 2-3 1. FC Köln | German Bundesliga |
| 20 | Fri 17 Dec 2021 | 90-4 v Bayern MunichBayern Munich 4-0 VfL Wolfsburg | German Bundesliga |
| 21 | Sun 9 Jan 2022 | 90-1 v VfL BochumVfL Bochum 1-0 VfL Wolfsburg | German Bundesliga |
| 22 | Sat 15 Jan 2022 | 90-0 v Hertha BerlinVfL Wolfsburg 0-0 Hertha Berlin | German Bundesliga |
| 23 | Sun 23 Jan 2022 | 90-2 v RB LeipzigRB Leipzig 2-0 VfL Wolfsburg | German Bundesliga |
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