| 1 | Sat 21 Aug 2021 | 42-0 v Mainz 05VfL Bochum 2-0 Mainz 05 | German Bundesliga |
| 2 | Sun 26 Sep 2021 | 4 0-0 v VfB StuttgartVfL Bochum 0-0 VfB Stuttgart | German Bundesliga |
| 3 | Sat 2 Oct 2021 | 40-3 v RB LeipzigRB Leipzig 3-0 VfL Bochum | German Bundesliga |
| 4 | Sat 16 Oct 2021 | 4 1-0 v Greuther FürthGreuther Fürth 0-1 VfL Bochum | German Bundesliga |
| 5 | Sun 24 Oct 2021 | 42-0 v Eintracht FrankfurtVfL Bochum 2-0 Eintracht Frankfurt | German Bundesliga |
| 6 | Sun 31 Oct 2021 | 4 1-2 v Borussia MönchengladbachBorussia Mönchengladbach 2-1 VfL Bochum | German Bundesliga |
| 7 | Sat 6 Nov 2021 | 42-0 v 1899 HoffenheimVfL Bochum 2-0 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 20 Nov 2021 | 4 0-1 v Bayer 04 LeverkusenBayer 04 Leverkusen 1-0 VfL Bochum | German Bundesliga |
| 9 | Sat 27 Nov 2021 | 42-1 v SC FreiburgVfL Bochum 2-1 SC Freiburg | German Bundesliga |
| 10 | Sat 4 Dec 2021 | 43-2 v FC AugsburgFC Augsburg 2-3 VfL Bochum | German Bundesliga |
| 11 | Sat 11 Dec 2021 | 41-1 v Borussia DortmundVfL Bochum 1-1 Borussia Dortmund | German Bundesliga |
| 12 | Tue 14 Dec 2021 | 40-2 v Arminia BielefeldArminia Bielefeld 2-0 VfL Bochum | German Bundesliga |
| 13 | Sat 18 Dec 2021 | 4 0-1 v 1. FC Union BerlinVfL Bochum 0-1 1. FC Union Berlin | German Bundesliga |
| 14 | Sat 12 Feb 2022 | 44-2 v Bayern MunichVfL Bochum 4-2 Bayern Munich | German Bundesliga |
| 15 | Sat 5 Mar 2022 | 42-1 v Greuther FürthVfL Bochum 2-1 Greuther Fürth | German Bundesliga |
| 16 | Sun 13 Mar 2022 | 41-2 v Eintracht FrankfurtEintracht Frankfurt 2-1 VfL Bochum | German Bundesliga |
| 17 | Fri 18 Mar 2022 | 4 0-2 v Borussia MönchengladbachVfL Bochum 0-2 Borussia Mönchengladbach | German Bundesliga |
| 18 | Sat 2 Apr 2022 | 42-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 VfL Bochum | German Bundesliga |
| 19 | Sat 30 Apr 2022 | 4 4-3 v Borussia DortmundBorussia Dortmund 3-4 VfL Bochum | German Bundesliga |
| 20 | Fri 6 May 2022 | 42-1 v Arminia BielefeldVfL Bochum 2-1 Arminia Bielefeld | German Bundesliga |
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