| 1 | Sat 14 Aug 2021 | 35-1 v Greuther FürthVfB Stuttgart 5-1 Greuther Fürth | German Bundesliga |
| 2 | Fri 20 Aug 2021 | 30-4 v RB LeipzigRB Leipzig 4-0 VfB Stuttgart | German Bundesliga |
| 3 | Sat 28 Aug 2021 | 32-3 v SC FreiburgVfB Stuttgart 2-3 SC Freiburg | German Bundesliga |
| 4 | Sun 12 Sep 2021 | 31-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 VfB Stuttgart | German Bundesliga |
| 5 | Sun 19 Sep 2021 | 31-3 v Bayer 04 LeverkusenVfB Stuttgart 1-3 Bayer 04 Leverkusen | German Bundesliga |
| 6 | Sun 26 Sep 2021 | 3 0-0 v VfL BochumVfL Bochum 0-0 VfB Stuttgart | German Bundesliga |
| 7 | Sat 2 Oct 2021 | 33-1 v 1899 HoffenheimVfB Stuttgart 3-1 1899 Hoffenheim | German Bundesliga |
| 8 | Sat 16 Oct 2021 | 31-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-1 VfB Stuttgart | German Bundesliga |
| 9 | Sun 24 Oct 2021 | 31-1 v 1. FC Union BerlinVfB Stuttgart 1-1 1. FC Union Berlin | German Bundesliga |
| 10 | Sun 31 Oct 2021 | 31-4 v FC AugsburgFC Augsburg 4-1 VfB Stuttgart | German Bundesliga |
| 11 | Sat 6 Nov 2021 | 30-1 v Arminia BielefeldVfB Stuttgart 0-1 Arminia Bielefeld | German Bundesliga |
| 12 | Sat 20 Nov 2021 | 31-2 v Borussia DortmundBorussia Dortmund 2-1 VfB Stuttgart | German Bundesliga |
| 13 | Fri 26 Nov 2021 | 32-1 v Mainz 05VfB Stuttgart 2-1 Mainz 05 | German Bundesliga |
| 14 | Sun 5 Dec 2021 | 32-2 v Hertha BerlinVfB Stuttgart 2-2 Hertha Berlin | German Bundesliga |
| 15 | Sat 11 Dec 2021 | 32-0 v VfL WolfsburgVfL Wolfsburg 0-2 VfB Stuttgart | German Bundesliga |
| 16 | Tue 14 Dec 2021 | 30-5 v Bayern MunichVfB Stuttgart 0-5 Bayern Munich | German Bundesliga |
| 17 | Sun 19 Dec 2021 | 30-1 v 1. FC Köln1. FC Köln 1-0 VfB Stuttgart | German Bundesliga |
| 18 | Sat 8 Jan 2022 | 30-0 v Greuther FürthGreuther Fürth 0-0 VfB Stuttgart | German Bundesliga |
| 19 | Sat 15 Jan 2022 | 30-2 v RB LeipzigVfB Stuttgart 0-2 RB Leipzig | German Bundesliga |
| 20 | Sat 22 Jan 2022 | 30-2 v SC FreiburgSC Freiburg 2-0 VfB Stuttgart | German Bundesliga |
| 21 | Sat 5 Feb 2022 | 32-3 v Eintracht FrankfurtVfB Stuttgart 2-3 Eintracht Frankfurt | German Bundesliga |
| 22 | Sat 12 Feb 2022 | 3 2-4 v Bayer 04 LeverkusenBayer 04 Leverkusen 4-2 VfB Stuttgart | German Bundesliga |
| 23 | Sat 19 Feb 2022 | 31-1 v VfL BochumVfB Stuttgart 1-1 VfL Bochum | German Bundesliga |
| 24 | Fri 25 Feb 2022 | 31-2 v 1899 Hoffenheim1899 Hoffenheim 2-1 VfB Stuttgart | German Bundesliga |
| 25 | Sat 5 Mar 2022 | 33-2 v Borussia MönchengladbachVfB Stuttgart 3-2 Borussia Mönchengladbach | German Bundesliga |
| 26 | Sat 12 Mar 2022 | 31-1 v 1. FC Union Berlin1. FC Union Berlin 1-1 VfB Stuttgart | German Bundesliga |
| 27 | Sat 19 Mar 2022 | 33-2 v FC AugsburgVfB Stuttgart 3-2 FC Augsburg | German Bundesliga |
| 28 | Sat 2 Apr 2022 | 31-1 v Arminia BielefeldArminia Bielefeld 1-1 VfB Stuttgart | German Bundesliga |
| 29 | Fri 8 Apr 2022 | 30-2 v Borussia DortmundVfB Stuttgart 0-2 Borussia Dortmund | German Bundesliga |
| 30 | Sun 24 Apr 2022 | 3 0-2 v Hertha BerlinHertha Berlin 2-0 VfB Stuttgart | German Bundesliga |
| 31 | Sat 30 Apr 2022 | 3 1-1 v VfL WolfsburgVfB Stuttgart 1-1 VfL Wolfsburg | German Bundesliga |
| 32 | Sun 8 May 2022 | 32-2 v Bayern MunichBayern Munich 2-2 VfB Stuttgart | German Bundesliga |
| 33 | Sat 14 May 2022 | 32-1 v 1. FC KölnVfB Stuttgart 2-1 1. FC Köln | German Bundesliga |
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