| 1 | Sat 2 Aug | 42 1-1 v Colchester UnitedColchester United 1-1 Tranmere Rovers | Sky Bet League Two |
| 2 | Sat 9 Aug | 424-0 v Shrewsbury TownTranmere Rovers 4-0 Shrewsbury Town | Sky Bet League Two |
| 3 | Sat 16 Aug | 421-1 v GillinghamTranmere Rovers 1-1 Gillingham | Sky Bet League Two |
| 4 | Sat 23 Aug | 42 2-0 v Crawley TownCrawley Town 0-2 Tranmere Rovers | Sky Bet League Two |
| 5 | Sat 30 Aug | 421-2 v Notts CountyTranmere Rovers 1-2 Notts County | Sky Bet League Two |
| 6 | Sat 13 Sep | 421-1 v Newport CountyTranmere Rovers 1-1 Newport County | Sky Bet League Two |
| 7 | Sat 20 Sep | 422-4 v WalsallWalsall 4-2 Tranmere Rovers | Sky Bet League Two |
| 8 | Sat 27 Sep | 420-0 v Cambridge UnitedTranmere Rovers 0-0 Cambridge United | Sky Bet League Two |
| 9 | Sat 4 Oct | 423-3 v BromleyBromley 3-3 Tranmere Rovers | Sky Bet League Two |
| 10 | Sat 11 Oct | 420-2 v BarnetTranmere Rovers 0-2 Barnet | Sky Bet League Two |
| 11 | Sat 18 Oct | 424-1 v Bristol RoversBristol Rovers 1-4 Tranmere Rovers | Sky Bet League Two |
| 12 | Tue 28 Oct | 421-1 v Accrington StanleyAccrington Stanley 1-1 Tranmere Rovers | Sky Bet League Two |
| 13 | Sat 8 Nov | 421-2 v Swindon TownSwindon Town 2-1 Tranmere Rovers | Sky Bet League Two |
| 14 | Tue 11 Nov | 422-1 v BlackpoolTranmere Rovers 2-1 Blackpool | EFL Trophy Northern Group B |
| 15 | Sat 22 Nov | 422-2 v Milton Keynes DonsTranmere Rovers 2-2 Milton Keynes Dons | Sky Bet League Two |
| 16 | Thu 27 Nov | 42 2-1 v Grimsby TownGrimsby Town 1-2 Tranmere Rovers | Sky Bet League Two |
| 17 | Tue 2 Dec | 420-3 v Fleetwood TownTranmere Rovers 0-3 Fleetwood Town | EFL Trophy Round of 32 |
| 18 | Tue 9 Dec | 423-0 v BarrowBarrow 0-3 Tranmere Rovers | Sky Bet League Two |
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