| 1 | Sun 15 Aug 2021 | 41-0 v Manchester CityTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Thu 19 Aug 2021 | 40-1 v Paços de FerreiraPaços de Ferreira 1-0 Tottenham Hotspur | UEFA Europa Conference League |
| 3 | Thu 26 Aug 2021 | 4 3-0 v Paços de FerreiraTottenham Hotspur 3-0 Paços de Ferreira | UEFA Europa Conference League |
| 4 | Sun 19 Sep 2021 | 40-3 v ChelseaTottenham Hotspur 0-3 Chelsea | Premier League |
| 5 | Wed 22 Sep 2021 | 42-2 v Wolverhampton WanderersWolverhampton Wanderers 2-2 Tottenham Hotspur | Carabao Cup Third Round |
| 6 | Thu 30 Sep 2021 | 45-1 v Mura Murska SobotaTottenham Hotspur 5-1 Mura Murska Sobota | UEFA Europa Conference League |
| 7 | Sun 3 Oct 2021 | 4 2-1 v Aston VillaTottenham Hotspur 2-1 Aston Villa | Premier League |
| 8 | Sun 17 Oct 2021 | 43-2 v Newcastle UnitedNewcastle United 2-3 Tottenham Hotspur | Premier League |
| 9 | Sun 24 Oct 2021 | 4 0-1 v West Ham UnitedWest Ham United 1-0 Tottenham Hotspur | Premier League |
| 10 | Wed 27 Oct 2021 | 41-0 v BurnleyBurnley 0-1 Tottenham Hotspur | Carabao Cup Round of 16 |
| 11 | Sat 30 Oct 2021 | 4 0-3 v Manchester UnitedTottenham Hotspur 0-3 Manchester United | Premier League |
| 12 | Thu 4 Nov 2021 | 4 3-2 v VitesseTottenham Hotspur 3-2 Vitesse | UEFA Europa Conference League |
| 13 | Sun 7 Nov 2021 | 4 0-0 v EvertonEverton 0-0 Tottenham Hotspur | Premier League |
| 14 | Sat 5 Feb 2022 | 43-1 v Brighton & Hove AlbionTottenham Hotspur 3-1 Brighton & Hove Albion | Emirates FA Cup Fourth Round |
| 15 | Wed 9 Feb 2022 | 4 2-3 v SouthamptonTottenham Hotspur 2-3 Southampton | Premier League |
| 16 | Sun 13 Feb 2022 | 40-2 v Wolverhampton WanderersTottenham Hotspur 0-2 Wolverhampton Wanderers | Premier League |
| 17 | Sat 19 Feb 2022 | 4 3-2 v Manchester CityManchester City 2-3 Tottenham Hotspur | Premier League |
| 18 | Wed 23 Feb 2022 | 40-1 v BurnleyBurnley 1-0 Tottenham Hotspur | Premier League |
| 19 | Sat 26 Feb 2022 | 44-0 v Leeds UnitedLeeds United 0-4 Tottenham Hotspur | Premier League |
| 20 | Tue 1 Mar 2022 | 4 0-1 v MiddlesbroughMiddlesbrough 1-0 Tottenham Hotspur | Emirates FA Cup Fifth Round |
| 21 | Mon 7 Mar 2022 | 4 5-0 v EvertonTottenham Hotspur 5-0 Everton | Premier League |
| 22 | Sat 12 Mar 2022 | 42-3 v Manchester UnitedManchester United 3-2 Tottenham Hotspur | Premier League |
| 23 | Wed 16 Mar 2022 | 4 2-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-2 Tottenham Hotspur | Premier League |
| 24 | Sun 20 Mar 2022 | 43-1 v West Ham UnitedTottenham Hotspur 3-1 West Ham United | Premier League |
| 25 | Sun 3 Apr 2022 | 45-1 v Newcastle UnitedTottenham Hotspur 5-1 Newcastle United | Premier League |
| 26 | Sat 9 Apr 2022 | 44-0 v Aston VillaAston Villa 0-4 Tottenham Hotspur | Premier League |
| 27 | Sat 16 Apr 2022 | 40-1 v Brighton & Hove AlbionTottenham Hotspur 0-1 Brighton & Hove Albion | Premier League |
| 28 | Sat 23 Apr 2022 | 40-0 v BrentfordBrentford 0-0 Tottenham Hotspur | Premier League |
| 29 | Sun 1 May 2022 | 43-1 v Leicester CityTottenham Hotspur 3-1 Leicester City | Premier League |
| 30 | Sat 7 May 2022 | 41-1 v LiverpoolLiverpool 1-1 Tottenham Hotspur | Premier League |
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