| 1 | Sun 8 Aug 2021 | 10-2 v AngersStrasbourg 0-2 Angers | French Ligue 1 |
| 2 | Sat 14 Aug 2021 | 12-4 v Paris St GermainParis St Germain 4-2 Strasbourg | French Ligue 1 |
| 3 | Sun 29 Aug 2021 | 13-1 v BrestStrasbourg 3-1 Brest | French Ligue 1 |
| 4 | Sun 12 Sep 2021 | 11-3 v LyonLyon 3-1 Strasbourg | French Ligue 1 |
| 5 | Fri 17 Sep 2021 | 13-0 v MetzStrasbourg 3-0 Metz | French Ligue 1 |
| 6 | Wed 22 Sep 2021 | 11-0 v LensLens 0-1 Strasbourg | French Ligue 1 |
| 7 | Sat 25 Sep 2021 | 11-2 v LilleStrasbourg 1-2 Lille | French Ligue 1 |
| 8 | Sat 2 Oct 2021 | 11-1 v MontpellierMontpellier 1-1 Strasbourg | French Ligue 1 |
| 9 | Sun 17 Oct 2021 | 15-1 v Saint ÉtienneStrasbourg 5-1 Saint Étienne | French Ligue 1 |
| 10 | Sun 24 Oct 2021 | 10-1 v RennesRennes 1-0 Strasbourg | French Ligue 1 |
| 11 | Sun 31 Oct 2021 | 14-0 v LorientStrasbourg 4-0 Lorient | French Ligue 1 |
| 12 | Sun 7 Nov 2021 | 12-2 v NantesNantes 2-2 Strasbourg | French Ligue 1 |
| 13 | Sun 21 Nov 2021 | 11-1 v ReimsStrasbourg 1-1 Reims | French Ligue 1 |
| 14 | Sun 28 Nov 2021 | 11-1 v MonacoMonaco 1-1 Strasbourg | French Ligue 1 |
| 15 | Wed 1 Dec 2021 | 15-2 v BordeauxStrasbourg 5-2 Bordeaux | French Ligue 1 |
| 16 | Sun 5 Dec 2021 | 13-0 v NiceNice 0-3 Strasbourg | French Ligue 1 |
| 17 | Sun 12 Dec 2021 | 10-2 v MarseilleStrasbourg 0-2 Marseille | French Ligue 1 |
| 18 | Sun 16 Jan 2022 | 13-1 v MontpellierStrasbourg 3-1 Montpellier | French Ligue 1 |
| 19 | Wed 19 Jan 2022 | 12-0 v ClermontClermont 0-2 Strasbourg | French Ligue 1 |
| 20 | Sun 23 Jan 2022 | 13-4 v BordeauxBordeaux 4-3 Strasbourg | French Ligue 1 |
| 21 | Sun 6 Feb 2022 | 1 1-0 v NantesStrasbourg 1-0 Nantes | French Ligue 1 |
| 22 | Sun 13 Feb 2022 | 11-0 v AngersAngers 0-1 Strasbourg | French Ligue 1 |
| 23 | Sun 20 Feb 2022 | 12-2 v Saint ÉtienneSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 24 | Sat 26 Feb 2022 | 10-0 v NiceStrasbourg 0-0 Nice | French Ligue 1 |
| 25 | Sun 6 Mar 2022 | 11-1 v ReimsReims 1-1 Strasbourg | French Ligue 1 |
| 26 | Sun 13 Mar 2022 | 11-0 v MonacoStrasbourg 1-0 Monaco | French Ligue 1 |
| 27 | Sun 20 Mar 2022 | 10-0 v LorientLorient 0-0 Strasbourg | French Ligue 1 |
| 28 | Sun 3 Apr 2022 | 11-0 v LensStrasbourg 1-0 Lens | French Ligue 1 |
| 29 | Sun 10 Apr 2022 | 11-1 v LyonStrasbourg 1-1 Lyon | French Ligue 1 |
| 30 | Sun 17 Apr 2022 | 11-1 v TroyesTroyes 1-1 Strasbourg | French Ligue 1 |
| 31 | Wed 20 Apr 2022 | 12-1 v RennesStrasbourg 2-1 Rennes | French Ligue 1 |
| 32 | Sun 24 Apr 2022 | 10-1 v LilleLille 1-0 Strasbourg | French Ligue 1 |
| 33 | Fri 29 Apr 2022 | 13-3 v Paris St GermainStrasbourg 3-3 Paris St Germain | French Ligue 1 |
| 34 | Sat 7 May 2022 | 11-0 v BrestBrest 0-1 Strasbourg | French Ligue 1 |
| 35 | Sat 14 May 2022 | 11-0 v ClermontStrasbourg 1-0 Clermont | French Ligue 1 |
| 36 | Sat 21 May 2022 | 10-4 v MarseilleMarseille 4-0 Strasbourg | French Ligue 1 |
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