| 1 | Fri 6 Aug 2021 | 23-0 v VizelaSporting Lisbon 3-0 Vizela | Portuguese Primeira Liga |
| 2 | Sat 14 Aug 2021 | 2 2-1 v Sporting BragaSporting Braga 1-2 Sporting Lisbon | Portuguese Primeira Liga |
| 3 | Sat 11 Sep 2021 | 21-1 v FC PortoSporting Lisbon 1-1 FC Porto | Portuguese Primeira Liga |
| 4 | Wed 15 Sep 2021 | 21-5 v AjaxSporting Lisbon 1-5 Ajax | UEFA Champions League Group C |
| 5 | Sun 19 Sep 2021 | 21-0 v Estoril PraiaEstoril Praia 0-1 Sporting Lisbon | Portuguese Primeira Liga |
| 6 | Tue 28 Sep 2021 | 20-1 v Borussia DortmundBorussia Dortmund 1-0 Sporting Lisbon | UEFA Champions League Group C |
| 7 | Sat 2 Oct 2021 | 22-1 v AroucaArouca 1-2 Sporting Lisbon | Portuguese Primeira Liga |
| 8 | Tue 19 Oct 2021 | 24-1 v BeşiktaşBeşiktaş 1-4 Sporting Lisbon | UEFA Champions League Group C |
| 9 | Sat 23 Oct 2021 | 21-0 v MoreirenseSporting Lisbon 1-0 Moreirense | Portuguese Primeira Liga |
| 10 | Sat 30 Oct 2021 | 21-0 v Vitória GuimarãesSporting Lisbon 1-0 Vitória Guimarães | Portuguese Primeira Liga |
| 11 | Wed 3 Nov 2021 | 24-0 v BeşiktaşSporting Lisbon 4-0 Beşiktaş | UEFA Champions League Group C |
| 12 | Sun 7 Nov 2021 | 22-0 v Paços de FerreiraPaços de Ferreira 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 13 | Wed 24 Nov 2021 | 23-1 v Borussia DortmundSporting Lisbon 3-1 Borussia Dortmund | UEFA Champions League Group C |
| 14 | Fri 3 Dec 2021 | 23-1 v BenficaBenfica 1-3 Sporting Lisbon | Portuguese Primeira Liga |
| 15 | Tue 7 Dec 2021 | 22-4 v AjaxAjax 4-2 Sporting Lisbon | UEFA Champions League Group C |
| 16 | Sat 11 Dec 2021 | 22-0 v BoavistaSporting Lisbon 2-0 Boavista | Portuguese Primeira Liga |
| 17 | Sat 18 Dec 2021 | 23-0 v Gil VicenteGil Vicente 0-3 Sporting Lisbon | Portuguese Primeira Liga |
| 18 | Wed 29 Dec 2021 | 23-2 v PortimonenseSporting Lisbon 3-2 Portimonense | Portuguese Primeira Liga |
| 19 | Fri 7 Jan 2022 | 2 2-3 v Santa ClaraSanta Clara 3-2 Sporting Lisbon | Portuguese Primeira Liga |
| 20 | Sun 16 Jan 2022 | 22-0 v VizelaVizela 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 21 | Sat 22 Jan 2022 | 21-2 v Sporting BragaSporting Lisbon 1-2 Sporting Braga | Portuguese Primeira Liga |
| 22 | Sun 6 Feb 2022 | 22-0 v FamalicãoSporting Lisbon 2-0 Famalicão | Portuguese Primeira Liga |
| 23 | Fri 11 Feb 2022 | 2 2-2 v FC PortoFC Porto 2-2 Sporting Lisbon | Portuguese Primeira Liga |
| 24 | Tue 15 Feb 2022 | 20-5 v Manchester CitySporting Lisbon 0-5 Manchester City | UEFA Champions League Round of 16 |
| 25 | Sun 20 Feb 2022 | 2 3-0 v Estoril PraiaSporting Lisbon 3-0 Estoril Praia | Portuguese Primeira Liga |
| 26 | Sat 26 Feb 2022 | 21-1 v MarítimoMarítimo 1-1 Sporting Lisbon | Portuguese Primeira Liga |
| 27 | Sat 5 Mar 2022 | 22-0 v AroucaSporting Lisbon 2-0 Arouca | Portuguese Primeira Liga |
| 28 | Wed 9 Mar 2022 | 20-0 v Manchester CityManchester City 0-0 Sporting Lisbon | UEFA Champions League Round of 16 |
| 29 | Mon 14 Mar 2022 | 2 2-0 v MoreirenseMoreirense 0-2 Sporting Lisbon | Portuguese Primeira Liga |
| 30 | Sat 19 Mar 2022 | 23-1 v Vitória GuimarãesVitória Guimarães 1-3 Sporting Lisbon | Portuguese Primeira Liga |
| 31 | Sun 3 Apr 2022 | 22-0 v Paços de FerreiraSporting Lisbon 2-0 Paços de Ferreira | Portuguese Primeira Liga |
| 32 | Sat 9 Apr 2022 | 2 3-1 v TondelaTondela 1-3 Sporting Lisbon | Portuguese Primeira Liga |
| 33 | Sun 1 May 2022 | 2 4-1 v Gil VicenteSporting Lisbon 4-1 Gil Vicente | Portuguese Primeira Liga |
| 34 | Sat 7 May 2022 | 23-2 v PortimonensePortimonense 2-3 Sporting Lisbon | Portuguese Primeira Liga |
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