| 1 | Sat 24 Jul 2021 | 33-0 v KV OostendeKV Oostende 0-3 Sporting de Charleroi | Belgian First Division A |
| 2 | Sat 31 Jul 2021 | 30-0 v Sint-Truidense VVSporting de Charleroi 0-0 Sint-Truidense VV | Belgian First Division A |
| 3 | Sun 8 Aug 2021 | 3 1-1 v Oud-Heverlee LeuvenOud-Heverlee Leuven 1-1 Sporting de Charleroi | Belgian First Division A |
| 4 | Fri 13 Aug 2021 | 31-1 v Royal AntwerpSporting de Charleroi 1-1 Royal Antwerp | Belgian First Division A |
| 5 | Sun 22 Aug 2021 | 32-2 v SV Zulte WaregemSV Zulte Waregem 2-2 Sporting de Charleroi | Belgian First Division A |
| 6 | Sat 28 Aug 2021 | 35-2 v Germinal BeerschotSporting de Charleroi 5-2 Germinal Beerschot | Belgian First Division A |
| 7 | Sat 18 Sep 2021 | 30-1 v Club BruggeSporting de Charleroi 0-1 Club Brugge | Belgian First Division A |
| 8 | Sun 26 Sep 2021 | 30-2 v MechelenSporting de Charleroi 0-2 Mechelen | Belgian First Division A |
| 9 | Sat 2 Oct 2021 | 3 2-2 v KV KortrijkKV Kortrijk 2-2 Sporting de Charleroi | Belgian First Division A |
| 10 | Sun 17 Oct 2021 | 32-0 v KRC GenkSporting de Charleroi 2-0 KRC Genk | Belgian First Division A |
| 11 | Sat 30 Oct 2021 | 33-0 v KAS EupenSporting de Charleroi 3-0 KAS Eupen | Belgian First Division A |
| 12 | Sat 20 Nov 2021 | 32-1 v Cercle BruggeCercle Brugge 1-2 Sporting de Charleroi | Belgian First Division A |
| 13 | Sat 27 Nov 2021 | 31-3 v RSC AnderlechtSporting de Charleroi 1-3 RSC Anderlecht | Belgian First Division A |
| 14 | Sun 5 Dec 2021 | 33-0 v Standard LiègeStandard Liège 0-3 Sporting de Charleroi | Belgian First Division A |
| 15 | Fri 10 Dec 2021 | 31-0 v KV OostendeSporting de Charleroi 1-0 KV Oostende | Belgian First Division A |
| 16 | Thu 16 Dec 2021 | 3 2-4 v KRC GenkKRC Genk 4-2 Sporting de Charleroi | Belgian First Division A |
| 17 | Sun 19 Dec 2021 | 34-0 v KAS EupenKAS Eupen 0-4 Sporting de Charleroi | Belgian First Division A |
| 18 | Sun 16 Jan 2022 | 30-3 v Royal AntwerpRoyal Antwerp 3-0 Sporting de Charleroi | Belgian First Division A |
| 19 | Sat 22 Jan 2022 | 30-0 v KAA GentSporting de Charleroi 0-0 KAA Gent | Belgian First Division A |
| 20 | Fri 28 Jan 2022 | 31-0 v Sint-Truidense VVSint-Truidense VV 0-1 Sporting de Charleroi | Belgian First Division A |
| 21 | Fri 4 Feb 2022 | 32-0 v SeraingSporting de Charleroi 2-0 Seraing | Belgian First Division A |
| 22 | Sun 13 Feb 2022 | 30-2 v Club BruggeClub Brugge 2-0 Sporting de Charleroi | Belgian First Division A |
| 23 | Fri 25 Feb 2022 | 33-2 v Germinal BeerschotGerminal Beerschot 2-3 Sporting de Charleroi | Belgian First Division A |
| 24 | Sun 6 Mar 2022 | 30-0 v Standard LiègeSporting de Charleroi 0-0 Standard Liège | Belgian First Division A |
| 25 | Sat 12 Mar 2022 | 32-2 v MechelenMechelen 2-2 Sporting de Charleroi | Belgian First Division A |
| 26 | Sat 19 Mar 2022 | 3 5-0 v Cercle BruggeSporting de Charleroi 5-0 Cercle Brugge | Belgian First Division A |
| 27 | Sun 3 Apr 2022 | 30-4 v RSC AnderlechtRSC Anderlecht 4-0 Sporting de Charleroi | Belgian First Division A |
| 28 | Sun 10 Apr 2022 | 33-0 v SV Zulte WaregemSporting de Charleroi 3-0 SV Zulte Waregem | Belgian First Division A |
| 29 | Sat 23 Apr 2022 | 30-1 v MechelenMechelen 1-0 Sporting de Charleroi | Belgian First Division A Play-off |
| 30 | Sat 30 Apr 2022 | 3 1-3 v KAA GentSporting de Charleroi 1-3 KAA Gent | Belgian First Division A Play-off |
| 31 | Fri 6 May 2022 | 32-2 v KRC GenkSporting de Charleroi 2-2 KRC Genk | Belgian First Division A Play-off |
| 32 | Tue 10 May 2022 | 32-3 v KRC GenkKRC Genk 3-2 Sporting de Charleroi | Belgian First Division A Play-off |
| 33 | Sat 14 May 2022 | 33-2 v MechelenSporting de Charleroi 3-2 Mechelen | Belgian First Division A Play-off |
| 34 | Sat 21 May 2022 | 32-1 v KAA GentKAA Gent 1-2 Sporting de Charleroi | Belgian First Division A Play-off |