| 1 | Fri 30 Jul 2021 | 21-0 v Krylia SovetovKrylia Sovetov 0-1 Spartak Moscow | Russian Premier League |
| 2 | Wed 4 Aug 2021 | 20-2 v BenficaSpartak Moscow 0-2 Benfica | UEFA Champions League Third Qualifying Round |
| 3 | Sat 7 Aug 2021 | 21-2 v Nizhny NovgorodSpartak Moscow 1-2 Nizhny Novgorod | Russian Premier League |
| 4 | Tue 10 Aug 2021 | 20-2 v BenficaBenfica 2-0 Spartak Moscow | UEFA Champions League Third Qualifying Round |
| 5 | Sat 14 Aug 2021 | 2 1-0 v UralSpartak Moscow 1-0 Ural | Russian Premier League |
| 6 | Sat 21 Aug 2021 | 21-1 v Arsenal TulaArsenal Tula 1-1 Spartak Moscow | Russian Premier League |
| 7 | Thu 26 Aug 2021 | 21-2 v SochiSpartak Moscow 1-2 Sochi | Russian Premier League |
| 8 | Sat 11 Sep 2021 | 2 3-1 v KhimkiSpartak Moscow 3-1 Khimki | Russian Premier League |
| 9 | Wed 15 Sep 2021 | 2 0-1 v Legia WarsawSpartak Moscow 0-1 Legia Warsaw | UEFA Europa League Group C |
| 10 | Mon 20 Sep 2021 | 20-1 v CSKA MoscowCSKA Moscow 1-0 Spartak Moscow | Russian Premier League |
| 11 | Sat 25 Sep 2021 | 22-0 v UfaSpartak Moscow 2-0 Ufa | Russian Premier League |
| 12 | Thu 30 Sep 2021 | 23-2 v NapoliNapoli 2-3 Spartak Moscow | UEFA Europa League Group C |
| 13 | Sun 3 Oct 2021 | 21-0 v Akhmat GroznyAkhmat Grozny 0-1 Spartak Moscow | Russian Premier League |
| 14 | Sat 16 Oct 2021 | 2 2-2 v Dinamo MoscowSpartak Moscow 2-2 Dinamo Moscow | Russian Premier League |
| 15 | Wed 20 Oct 2021 | 23-4 v Leicester CitySpartak Moscow 3-4 Leicester City | UEFA Europa League Group C |
| 16 | Sat 30 Oct 2021 | 21-1 v RostovSpartak Moscow 1-1 Rostov | Russian Premier League |
| 17 | Thu 4 Nov 2021 | 21-1 v Leicester CityLeicester City 1-1 Spartak Moscow | UEFA Europa League Group C |
| 18 | Sun 7 Nov 2021 | 21-1 v Lokomotiv MoscowSpartak Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 19 | Sat 20 Nov 2021 | 21-2 v FK KrasnodarFK Krasnodar 2-1 Spartak Moscow | Russian Premier League |
| 20 | Wed 24 Nov 2021 | 22-1 v NapoliSpartak Moscow 2-1 Napoli | UEFA Europa League Group C |
| 21 | Mon 29 Nov 2021 | 21-1 v UfaUfa 1-1 Spartak Moscow | Russian Premier League |
| 22 | Sat 4 Dec 2021 | 2 2-1 v Akhmat GroznySpartak Moscow 2-1 Akhmat Grozny | Russian Premier League |
| 23 | Thu 9 Dec 2021 | 21-0 v Legia WarsawLegia Warsaw 0-1 Spartak Moscow | UEFA Europa League Group C |
| 24 | Mon 13 Dec 2021 | 2 0-3 v SochiSochi 3-0 Spartak Moscow | Russian Premier League |
| 25 | Sat 26 Feb 2022 | 20-2 v CSKA MoscowSpartak Moscow 0-2 CSKA Moscow | Russian Premier League |
| 26 | Sun 6 Mar 2022 | 22-0 v Dinamo MoscowDinamo Moscow 0-2 Spartak Moscow | Russian Premier League |
| 27 | Sun 13 Mar 2022 | 21-2 v FK KrasnodarSpartak Moscow 1-2 FK Krasnodar | Russian Premier League |
| 28 | Sat 19 Mar 2022 | 21-1 v Nizhny NovgorodNizhny Novgorod 1-1 Spartak Moscow | Russian Premier League |
| 29 | Sat 2 Apr 2022 | 20-1 v Lokomotiv MoscowLokomotiv Moscow 1-0 Spartak Moscow | Russian Premier League |
| 30 | Sun 10 Apr 2022 | 2 3-0 v Arsenal TulaSpartak Moscow 3-0 Arsenal Tula | Russian Premier League |
| 31 | Sat 16 Apr 2022 | 21-1 v Rubin KazanSpartak Moscow 1-1 Rubin Kazan | Russian Premier League |
| 32 | Sun 24 Apr 2022 | 22-3 v RostovRostov 3-2 Spartak Moscow | Russian Premier League |
| 33 | Sun 1 May 2022 | 2 2-1 v Krylia SovetovSpartak Moscow 2-1 Krylia Sovetov | Russian Premier League |
| 34 | Sun 15 May 2022 | 21-1 v Zenit St PetersburgSpartak Moscow 1-1 Zenit St Petersburg | Russian Premier League |
| 35 | Sat 21 May 2022 | 21-2 v KhimkiKhimki 2-1 Spartak Moscow | Russian Premier League |
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