| 1 | Sat 11 Sep 2021 | 3 3-1 v KhimkiSpartak Moscow 3-1 Khimki | Russian Premier League |
| 2 | Mon 20 Sep 2021 | 30-1 v CSKA MoscowCSKA Moscow 1-0 Spartak Moscow | Russian Premier League |
| 3 | Sat 25 Sep 2021 | 32-0 v UfaSpartak Moscow 2-0 Ufa | Russian Premier League |
| 4 | Thu 30 Sep 2021 | 3 3-2 v NapoliNapoli 2-3 Spartak Moscow | UEFA Europa League Group C |
| 5 | Sun 3 Oct 2021 | 31-0 v Akhmat GroznyAkhmat Grozny 0-1 Spartak Moscow | Russian Premier League |
| 6 | Sat 16 Oct 2021 | 32-2 v Dinamo MoscowSpartak Moscow 2-2 Dinamo Moscow | Russian Premier League |
| 7 | Sun 24 Oct 2021 | 3 1-7 v Zenit St PetersburgZenit St Petersburg 7-1 Spartak Moscow | Russian Premier League |
| 8 | Thu 4 Nov 2021 | 31-1 v Leicester CityLeicester City 1-1 Spartak Moscow | UEFA Europa League Group C |
| 9 | Sun 7 Nov 2021 | 31-1 v Lokomotiv MoscowSpartak Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 10 | Sat 20 Nov 2021 | 3 1-2 v FK KrasnodarFK Krasnodar 2-1 Spartak Moscow | Russian Premier League |
| 11 | Wed 24 Nov 2021 | 32-1 v NapoliSpartak Moscow 2-1 Napoli | UEFA Europa League Group C |
| 12 | Mon 29 Nov 2021 | 31-1 v UfaUfa 1-1 Spartak Moscow | Russian Premier League |
| 13 | Thu 9 Dec 2021 | 31-0 v Legia WarsawLegia Warsaw 0-1 Spartak Moscow | UEFA Europa League Group C |
| 14 | Mon 13 Dec 2021 | 3 0-3 v SochiSochi 3-0 Spartak Moscow | Russian Premier League |
| 15 | Sun 6 Mar 2022 | 3 2-0 v Dinamo MoscowDinamo Moscow 0-2 Spartak Moscow | Russian Premier League |
| 16 | Sun 13 Mar 2022 | 31-2 v FK KrasnodarSpartak Moscow 1-2 FK Krasnodar | Russian Premier League |
| 17 | Sat 2 Apr 2022 | 3 0-1 v Lokomotiv MoscowLokomotiv Moscow 1-0 Spartak Moscow | Russian Premier League |
| 18 | Sun 24 Apr 2022 | 32-3 v RostovRostov 3-2 Spartak Moscow | Russian Premier League |
| 19 | Sun 1 May 2022 | 32-1 v Krylia SovetovSpartak Moscow 2-1 Krylia Sovetov | Russian Premier League |
| 20 | Sat 7 May 2022 | 33-1 v UralUral 1-3 Spartak Moscow | Russian Premier League |
| 21 | Sat 21 May 2022 | 31-2 v KhimkiKhimki 2-1 Spartak Moscow | Russian Premier League |
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