| 1 | Fri 30 Jul 2021 | 61-0 v Krylia SovetovKrylia Sovetov 0-1 Spartak Moscow | Russian Premier League |
| 2 | Wed 4 Aug 2021 | 60-2 v BenficaSpartak Moscow 0-2 Benfica | UEFA Champions League Third Qualifying Round |
| 3 | Sat 7 Aug 2021 | 61-2 v Nizhny NovgorodSpartak Moscow 1-2 Nizhny Novgorod | Russian Premier League |
| 4 | Tue 10 Aug 2021 | 60-2 v BenficaBenfica 2-0 Spartak Moscow | UEFA Champions League Third Qualifying Round |
| 5 | Sat 14 Aug 2021 | 61-0 v UralSpartak Moscow 1-0 Ural | Russian Premier League |
| 6 | Sat 21 Aug 2021 | 61-1 v Arsenal TulaArsenal Tula 1-1 Spartak Moscow | Russian Premier League |
| 7 | Thu 26 Aug 2021 | 61-2 v SochiSpartak Moscow 1-2 Sochi | Russian Premier League |
| 8 | Sat 11 Sep 2021 | 63-1 v KhimkiSpartak Moscow 3-1 Khimki | Russian Premier League |
| 9 | Wed 15 Sep 2021 | 60-1 v Legia WarsawSpartak Moscow 0-1 Legia Warsaw | UEFA Europa League Group C |
| 10 | Mon 20 Sep 2021 | 60-1 v CSKA MoscowCSKA Moscow 1-0 Spartak Moscow | Russian Premier League |
| 11 | Sat 25 Sep 2021 | 62-0 v UfaSpartak Moscow 2-0 Ufa | Russian Premier League |
| 12 | Thu 30 Sep 2021 | 6 3-2 v NapoliNapoli 2-3 Spartak Moscow | UEFA Europa League Group C |
| 13 | Sun 3 Oct 2021 | 6 1-0 v Akhmat GroznyAkhmat Grozny 0-1 Spartak Moscow | Russian Premier League |
| 14 | Sat 16 Oct 2021 | 62-2 v Dinamo MoscowSpartak Moscow 2-2 Dinamo Moscow | Russian Premier League |
| 15 | Wed 20 Oct 2021 | 63-4 v Leicester CitySpartak Moscow 3-4 Leicester City | UEFA Europa League Group C |
| 16 | Sun 24 Oct 2021 | 61-7 v Zenit St PetersburgZenit St Petersburg 7-1 Spartak Moscow | Russian Premier League |
| 17 | Sat 30 Oct 2021 | 61-1 v RostovSpartak Moscow 1-1 Rostov | Russian Premier League |
| 18 | Thu 4 Nov 2021 | 61-1 v Leicester CityLeicester City 1-1 Spartak Moscow | UEFA Europa League Group C |
| 19 | Sun 7 Nov 2021 | 61-1 v Lokomotiv MoscowSpartak Moscow 1-1 Lokomotiv Moscow | Russian Premier League |
| 20 | Sat 20 Nov 2021 | 6 1-2 v FK KrasnodarFK Krasnodar 2-1 Spartak Moscow | Russian Premier League |
| 21 | Wed 24 Nov 2021 | 62-1 v NapoliSpartak Moscow 2-1 Napoli | UEFA Europa League Group C |
| 22 | Mon 29 Nov 2021 | 6 1-1 v UfaUfa 1-1 Spartak Moscow | Russian Premier League |
| 23 | Sat 4 Dec 2021 | 6 2-1 v Akhmat GroznySpartak Moscow 2-1 Akhmat Grozny | Russian Premier League |
| 24 | Thu 9 Dec 2021 | 61-0 v Legia WarsawLegia Warsaw 0-1 Spartak Moscow | UEFA Europa League Group C |
| 25 | Sat 26 Feb 2022 | 60-2 v CSKA MoscowSpartak Moscow 0-2 CSKA Moscow | Russian Premier League |
| 26 | Sun 6 Mar 2022 | 6 2-0 v Dinamo MoscowDinamo Moscow 0-2 Spartak Moscow | Russian Premier League |
| 27 | Sun 13 Mar 2022 | 61-2 v FK KrasnodarSpartak Moscow 1-2 FK Krasnodar | Russian Premier League |
| 28 | Sat 19 Mar 2022 | 61-1 v Nizhny NovgorodNizhny Novgorod 1-1 Spartak Moscow | Russian Premier League |
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