| 1 | Sun 14 Sep | 180-0 v PortsmouthSouthampton 0-0 Portsmouth | Sky Bet Championship |
| 2 | Sat 20 Sep | 181-3 v Hull CityHull City 3-1 Southampton | Sky Bet Championship |
| 3 | Tue 23 Sep | 181-2 v LiverpoolLiverpool 2-1 Southampton | Carabao Cup Third Round |
| 4 | Sat 27 Sep | 181-1 v MiddlesbroughSouthampton 1-1 Middlesbrough | Sky Bet Championship |
| 5 | Tue 30 Sep | 182-1 v Sheffield UnitedSheffield United 1-2 Southampton | Sky Bet Championship |
| 6 | Sat 4 Oct | 181-1 v Derby CountyDerby County 1-1 Southampton | Sky Bet Championship |
| 7 | Sat 18 Oct | 180-0 v Swansea CitySouthampton 0-0 Swansea City | Sky Bet Championship |
| 8 | Tue 21 Oct | 18 1-3 v Bristol CityBristol City 3-1 Southampton | Sky Bet Championship |
| 9 | Sat 1 Nov | 180-2 v Preston North EndSouthampton 0-2 Preston North End | Sky Bet Championship |
| 10 | Wed 5 Nov | 182-1 v Queens Park RangersQueens Park Rangers 1-2 Southampton | Sky Bet Championship |
| 11 | Sat 8 Nov | 183-1 v Sheffield WednesdaySouthampton 3-1 Sheffield Wednesday | Sky Bet Championship |
| 12 | Sat 22 Nov | 185-1 v Charlton AthleticCharlton Athletic 1-5 Southampton | Sky Bet Championship |
| 13 | Tue 25 Nov | 183-0 v Leicester CitySouthampton 3-0 Leicester City | Sky Bet Championship |
| 14 | Sat 29 Nov | 18 2-3 v MillwallMillwall 3-2 Southampton | Sky Bet Championship |
| 15 | Sat 6 Dec | 183-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 16 | Tue 9 Dec | 183-2 v West Bromwich AlbionSouthampton 3-2 West Bromwich Albion | Sky Bet Championship |
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