| 1 | Tue 12 Aug | 151-0 v Northampton TownNorthampton Town 0-1 Southampton | Carabao Cup First Round |
| 2 | Sat 23 Aug | 15 1-2 v Stoke CitySouthampton 1-2 Stoke City | Sky Bet Championship |
| 3 | Tue 26 Aug | 153-0 v Norwich CityNorwich City 0-3 Southampton | Carabao Cup Second Round |
| 4 | Sat 30 Aug | 152-2 v WatfordWatford 2-2 Southampton | Sky Bet Championship |
| 5 | Tue 23 Sep | 151-2 v LiverpoolLiverpool 2-1 Southampton | Carabao Cup Third Round |
| 6 | Sat 27 Sep | 151-1 v MiddlesbroughSouthampton 1-1 Middlesbrough | Sky Bet Championship |
| 7 | Tue 30 Sep | 15 2-1 v Sheffield UnitedSheffield United 1-2 Southampton | Sky Bet Championship |
| 8 | Sat 4 Oct | 151-1 v Derby CountyDerby County 1-1 Southampton | Sky Bet Championship |
| 9 | Sat 18 Oct | 150-0 v Swansea CitySouthampton 0-0 Swansea City | Sky Bet Championship |
| 10 | Tue 21 Oct | 151-3 v Bristol CityBristol City 3-1 Southampton | Sky Bet Championship |
| 11 | Sat 25 Oct | 151-2 v Blackburn RoversBlackburn Rovers 2-1 Southampton | Sky Bet Championship |
| 12 | Sat 1 Nov | 150-2 v Preston North EndSouthampton 0-2 Preston North End | Sky Bet Championship |
| 13 | Wed 5 Nov | 15 2-1 v Queens Park RangersQueens Park Rangers 1-2 Southampton | Sky Bet Championship |
| 14 | Sat 8 Nov | 153-1 v Sheffield WednesdaySouthampton 3-1 Sheffield Wednesday | Sky Bet Championship |
| 15 | Sat 22 Nov | 155-1 v Charlton AthleticCharlton Athletic 1-5 Southampton | Sky Bet Championship |
| 16 | Tue 25 Nov | 153-0 v Leicester CitySouthampton 3-0 Leicester City | Sky Bet Championship |
| 17 | Sat 29 Nov | 152-3 v MillwallMillwall 3-2 Southampton | Sky Bet Championship |
| 18 | Sat 6 Dec | 153-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 19 | Tue 9 Dec | 153-2 v West Bromwich AlbionSouthampton 3-2 West Bromwich Albion | Sky Bet Championship |
| 20 | Sat 13 Dec | 151-2 v Norwich CityNorwich City 2-1 Southampton | Sky Bet Championship |
| 21 | Sat 20 Dec | 151-1 v Coventry CitySouthampton 1-1 Coventry City | Sky Bet Championship |
| 22 | Fri 26 Dec | 151-2 v Oxford UnitedOxford United 2-1 Southampton | Sky Bet Championship |
| 23 | Mon 29 Dec | 15 1-1 v Birmingham CityBirmingham City 1-1 Southampton | Sky Bet Championship |
| 24 | Thu 1 Jan | 15 0-0 v MillwallSouthampton 0-0 Millwall | Sky Bet Championship |
| 25 | Sun 4 Jan | 150-4 v MiddlesbroughMiddlesbrough 4-0 Southampton | Sky Bet Championship |
| 26 | Sat 10 Jan | 153-2 v Doncaster RoversDoncaster Rovers 2-3 Southampton | Emirates FA Cup Third Round |
| 27 | Sat 17 Jan | 151-2 v Hull CitySouthampton 1-2 Hull City | Sky Bet Championship |
| 28 | Wed 21 Jan | 151-0 v Sheffield UnitedSouthampton 1-0 Sheffield United | Sky Bet Championship |
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