| 1 | Sat 24 Aug | 180-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 2 | Wed 28 Aug | 185-3 v Cardiff CityCardiff City 3-5 Southampton | Carabao Cup Second Round |
| 3 | Sat 31 Aug | 181-3 v BrentfordBrentford 3-1 Southampton | Premier League |
| 4 | Sat 14 Sep | 180-3 v Manchester UnitedSouthampton 0-3 Manchester United | Premier League |
| 5 | Tue 17 Sep | 181-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 6 | Sat 21 Sep | 181-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 7 | Mon 30 Sep | 18 1-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton | Premier League |
| 8 | Sat 5 Oct | 181-3 v ArsenalArsenal 3-1 Southampton | Premier League |
| 9 | Sat 19 Oct | 18 2-3 v Leicester CitySouthampton 2-3 Leicester City | Premier League |
| 10 | Sat 26 Oct | 180-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 11 | Tue 29 Oct | 183-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 12 | Sat 2 Nov | 18 1-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 13 | Sat 9 Nov | 180-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 14 | Sun 24 Nov | 182-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 15 | Fri 29 Nov | 181-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-1 Southampton | Premier League |
| 16 | Wed 4 Dec | 181-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 17 | Sat 7 Dec | 180-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 18 | Sun 15 Dec | 18 0-5 v Tottenham HotspurSouthampton 0-5 Tottenham Hotspur | Premier League |
| 19 | Wed 18 Dec | 181-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 20 | Sun 22 Dec | 180-0 v FulhamFulham 0-0 Southampton | Premier League |
| 21 | Thu 26 Dec | 180-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 22 | Sun 29 Dec | 18 1-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 23 | Sun 12 Jan | 183-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 24 | Thu 16 Jan | 18 1-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 25 | Sun 19 Jan | 182-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 26 | Sat 25 Jan | 18 1-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 27 | Sat 1 Feb | 182-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 28 | Sat 8 Feb | 180-1 v BurnleySouthampton 0-1 Burnley | Emirates FA Cup Fourth Round |
| 29 | Sat 15 Feb | 181-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 30 | Sat 22 Feb | 180-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion | Premier League |
| 31 | Tue 25 Feb | 180-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 32 | Sat 8 Mar | 181-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 33 | Sat 15 Mar | 181-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 34 | Wed 2 Apr | 181-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 35 | Sun 6 Apr | 181-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 36 | Sat 12 Apr | 18 0-3 v Aston VillaSouthampton 0-3 Aston Villa | Premier League |
| 37 | Sat 19 Apr | 181-1 v West Ham UnitedWest Ham United 1-1 Southampton | Premier League |
| 38 | Sat 26 Apr | 181-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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