| 1 | Wed 28 Aug | 265-3 v Cardiff CityCardiff City 3-5 Southampton | Carabao Cup Second Round |
| 2 | Sat 14 Sep | 260-3 v Manchester UnitedSouthampton 0-3 Manchester United | Premier League |
| 3 | Tue 17 Sep | 261-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 4 | Sat 21 Sep | 261-1 v Ipswich TownSouthampton 1-1 Ipswich Town | Premier League |
| 5 | Mon 30 Sep | 261-3 v AFC BournemouthAFC Bournemouth 3-1 Southampton | Premier League |
| 6 | Tue 29 Oct | 263-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 7 | Sat 2 Nov | 261-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 8 | Sat 9 Nov | 26 0-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 9 | Sun 24 Nov | 262-3 v LiverpoolSouthampton 2-3 Liverpool | Premier League |
| 10 | Wed 18 Dec | 261-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 11 | Sun 22 Dec | 26 0-0 v FulhamFulham 0-0 Southampton | Premier League |
| 12 | Thu 26 Dec | 260-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 13 | Sun 29 Dec | 261-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 14 | Sat 4 Jan | 260-5 v BrentfordSouthampton 0-5 Brentford | Premier League |
| 15 | Sun 12 Jan | 263-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 16 | Thu 16 Jan | 261-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 17 | Sun 19 Jan | 26 2-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 18 | Sat 25 Jan | 261-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 19 | Sat 1 Feb | 262-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 20 | Sat 8 Feb | 260-1 v BurnleySouthampton 0-1 Burnley | Emirates FA Cup Fourth Round |
| 21 | Sat 15 Feb | 261-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 22 | Sat 22 Feb | 26 0-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion | Premier League |
| 23 | Sat 8 Mar | 261-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 24 | Sat 15 Mar | 261-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 25 | Wed 2 Apr | 261-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 26 | Sun 6 Apr | 26 1-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 27 | Sat 12 Apr | 260-3 v Aston VillaSouthampton 0-3 Aston Villa | Premier League |
| 28 | Sat 19 Apr | 261-1 v West Ham UnitedWest Ham United 1-1 Southampton | Premier League |
| 29 | Sat 26 Apr | 261-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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