| 1 | Sat 9 Aug | 462-1 v WrexhamSouthampton 2-1 Wrexham | Sky Bet Championship |
| 2 | Sun 17 Aug | 461-1 v Ipswich TownIpswich Town 1-1 Southampton | Sky Bet Championship |
| 3 | Sat 23 Aug | 461-2 v Stoke CitySouthampton 1-2 Stoke City | Sky Bet Championship |
| 4 | Sat 30 Aug | 462-2 v WatfordWatford 2-2 Southampton | Sky Bet Championship |
| 5 | Sun 14 Sep | 460-0 v PortsmouthSouthampton 0-0 Portsmouth | Sky Bet Championship |
| 6 | Tue 23 Sep | 461-2 v LiverpoolLiverpool 2-1 Southampton | Carabao Cup Third Round |
| 7 | Sat 27 Sep | 461-1 v MiddlesbroughSouthampton 1-1 Middlesbrough | Sky Bet Championship |
| 8 | Tue 30 Sep | 462-1 v Sheffield UnitedSheffield United 1-2 Southampton | Sky Bet Championship |
| 9 | Sat 18 Oct | 460-0 v Swansea CitySouthampton 0-0 Swansea City | Sky Bet Championship |
| 10 | Tue 21 Oct | 461-3 v Bristol CityBristol City 3-1 Southampton | Sky Bet Championship |
| 11 | Sat 25 Oct | 461-2 v Blackburn RoversBlackburn Rovers 2-1 Southampton | Sky Bet Championship |
| 12 | Sat 1 Nov | 460-2 v Preston North EndSouthampton 0-2 Preston North End | Sky Bet Championship |
| 13 | Wed 5 Nov | 462-1 v Queens Park RangersQueens Park Rangers 1-2 Southampton | Sky Bet Championship |
| 14 | Sat 8 Nov | 463-1 v Sheffield WednesdaySouthampton 3-1 Sheffield Wednesday | Sky Bet Championship |
| 15 | Sat 22 Nov | 465-1 v Charlton AthleticCharlton Athletic 1-5 Southampton | Sky Bet Championship |
| 16 | Tue 25 Nov | 463-0 v Leicester CitySouthampton 3-0 Leicester City | Sky Bet Championship |
| 17 | Sat 29 Nov | 462-3 v MillwallMillwall 3-2 Southampton | Sky Bet Championship |
| 18 | Sat 6 Dec | 463-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 19 | Tue 9 Dec | 463-2 v West Bromwich AlbionSouthampton 3-2 West Bromwich Albion | Sky Bet Championship |
| 20 | Sat 13 Dec | 461-2 v Norwich CityNorwich City 2-1 Southampton | Sky Bet Championship |
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