| 1 | Wed 28 Aug | 14 5-3 v Cardiff CityCardiff City 3-5 Southampton | Carabao Cup Second Round |
| 2 | Tue 17 Sep | 141-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 3 | Sat 26 Oct | 140-1 v Manchester CityManchester City 1-0 Southampton | Premier League |
| 4 | Tue 29 Oct | 143-2 v Stoke CitySouthampton 3-2 Stoke City | Carabao Cup Round of 16 |
| 5 | Wed 4 Dec | 141-5 v ChelseaSouthampton 1-5 Chelsea | Premier League |
| 6 | Sat 7 Dec | 140-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 7 | Wed 18 Dec | 141-2 v LiverpoolSouthampton 1-2 Liverpool | Carabao Cup Quarter Final |
| 8 | Sun 22 Dec | 140-0 v FulhamFulham 0-0 Southampton | Premier League |
| 9 | Thu 26 Dec | 140-1 v West Ham UnitedSouthampton 0-1 West Ham United | Premier League |
| 10 | Sun 29 Dec | 141-2 v Crystal PalaceCrystal Palace 2-1 Southampton | Premier League |
| 11 | Sat 4 Jan | 140-5 v BrentfordSouthampton 0-5 Brentford | Premier League |
| 12 | Sun 12 Jan | 143-0 v Swansea CitySouthampton 3-0 Swansea City | Emirates FA Cup Third Round |
| 13 | Thu 16 Jan | 141-3 v Manchester UnitedManchester United 3-1 Southampton | Premier League |
| 14 | Sun 19 Jan | 142-3 v Nottingham ForestNottingham Forest 3-2 Southampton | Premier League |
| 15 | Sat 25 Jan | 141-3 v Newcastle UnitedSouthampton 1-3 Newcastle United | Premier League |
| 16 | Sat 1 Feb | 142-1 v Ipswich TownIpswich Town 1-2 Southampton | Premier League |
| 17 | Sat 8 Feb | 14 0-1 v BurnleySouthampton 0-1 Burnley | Emirates FA Cup Fourth Round |
| 18 | Sat 15 Feb | 141-3 v AFC BournemouthSouthampton 1-3 AFC Bournemouth | Premier League |
| 19 | Sat 22 Feb | 140-4 v Brighton & Hove AlbionSouthampton 0-4 Brighton & Hove Albion | Premier League |
| 20 | Tue 25 Feb | 140-4 v ChelseaChelsea 4-0 Southampton | Premier League |
| 21 | Sat 26 Apr | 141-2 v FulhamSouthampton 1-2 Fulham | Premier League |
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