| 1 | Sat 9 Aug | 19 2-1 v WrexhamSouthampton 2-1 Wrexham | Sky Bet Championship |
| 2 | Tue 12 Aug | 191-0 v Northampton TownNorthampton Town 0-1 Southampton | Carabao Cup First Round |
| 3 | Sun 17 Aug | 191-1 v Ipswich TownIpswich Town 1-1 Southampton | Sky Bet Championship |
| 4 | Sat 23 Aug | 191-2 v Stoke CitySouthampton 1-2 Stoke City | Sky Bet Championship |
| 5 | Tue 26 Aug | 193-0 v Norwich CityNorwich City 0-3 Southampton | Carabao Cup Second Round |
| 6 | Sat 30 Aug | 192-2 v WatfordWatford 2-2 Southampton | Sky Bet Championship |
| 7 | Sun 14 Sep | 190-0 v PortsmouthSouthampton 0-0 Portsmouth | Sky Bet Championship |
| 8 | Sat 20 Sep | 191-3 v Hull CityHull City 3-1 Southampton | Sky Bet Championship |
| 9 | Tue 23 Sep | 19 1-2 v LiverpoolLiverpool 2-1 Southampton | Carabao Cup Third Round |
| 10 | Tue 30 Sep | 192-1 v Sheffield UnitedSheffield United 1-2 Southampton | Sky Bet Championship |
| 11 | Sat 18 Oct | 190-0 v Swansea CitySouthampton 0-0 Swansea City | Sky Bet Championship |
| 12 | Tue 21 Oct | 191-3 v Bristol CityBristol City 3-1 Southampton | Sky Bet Championship |
| 13 | Sat 25 Oct | 191-2 v Blackburn RoversBlackburn Rovers 2-1 Southampton | Sky Bet Championship |
| 14 | Sat 6 Dec | 193-1 v Birmingham CitySouthampton 3-1 Birmingham City | Sky Bet Championship |
| 15 | Tue 9 Dec | 193-2 v West Bromwich AlbionSouthampton 3-2 West Bromwich Albion | Sky Bet Championship |
| 16 | Sat 13 Dec | 191-2 v Norwich CityNorwich City 2-1 Southampton | Sky Bet Championship |
| 17 | Sat 20 Dec | 191-1 v Coventry CitySouthampton 1-1 Coventry City | Sky Bet Championship |
| 18 | Fri 26 Dec | 191-2 v Oxford UnitedOxford United 2-1 Southampton | Sky Bet Championship |
| 19 | Mon 29 Dec | 191-1 v Birmingham CityBirmingham City 1-1 Southampton | Sky Bet Championship |
| 20 | Thu 1 Jan | 190-0 v MillwallSouthampton 0-0 Millwall | Sky Bet Championship |
| 21 | Sun 4 Jan | 190-4 v MiddlesbroughMiddlesbrough 4-0 Southampton | Sky Bet Championship |
| 22 | Sat 10 Jan | 193-2 v Doncaster RoversDoncaster Rovers 2-3 Southampton | Emirates FA Cup Third Round |
| 23 | Sat 17 Jan | 191-2 v Hull CitySouthampton 1-2 Hull City | Sky Bet Championship |
| 24 | Tue 10 Feb | 194-3 v Leicester CityLeicester City 3-4 Southampton | Sky Bet Championship |
| 25 | Sat 14 Feb | 192-1 v Leicester CitySouthampton 2-1 Leicester City | Emirates FA Cup Fourth Round |
| 26 | Tue 24 Feb | 195-0 v Queens Park RangersSouthampton 5-0 Queens Park Rangers | Sky Bet Championship |
| 27 | Sat 28 Feb | 193-1 v Sheffield WednesdaySheffield Wednesday 1-3 Southampton | Sky Bet Championship |
| 28 | Wed 11 Mar | 191-1 v West Bromwich AlbionWest Bromwich Albion 1-1 Southampton | Sky Bet Championship |
| 29 | Sat 14 Mar | 19 2-1 v Coventry CityCoventry City 1-2 Southampton | Sky Bet Championship |
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