| 1 | Sat 6 Aug 2022 | 271-4 v Tottenham HotspurTottenham Hotspur 4-1 Southampton | Premier League |
| 2 | Tue 23 Aug 2022 | 273-0 v Cambridge UnitedCambridge United 0-3 Southampton | Carabao Cup Second Round |
| 3 | Tue 30 Aug 2022 | 272-1 v ChelseaSouthampton 2-1 Chelsea | Premier League |
| 4 | Sat 3 Sep 2022 | 27 0-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Southampton | Premier League |
| 5 | Fri 16 Sep 2022 | 270-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 6 | Sat 8 Oct 2022 | 270-4 v Manchester CityManchester City 4-0 Southampton | Premier League |
| 7 | Sun 16 Oct 2022 | 271-1 v West Ham UnitedSouthampton 1-1 West Ham United | Premier League |
| 8 | Wed 19 Oct 2022 | 271-0 v AFC BournemouthAFC Bournemouth 0-1 Southampton | Premier League |
| 9 | Sun 23 Oct 2022 | 271-1 v ArsenalSouthampton 1-1 Arsenal | Premier League |
| 10 | Sat 29 Oct 2022 | 270-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 11 | Wed 9 Nov 2022 | 271-1 v Sheffield WednesdaySouthampton 1-1 Sheffield Wednesday | Carabao Cup Third Round |
| 12 | Mon 26 Dec 2022 | 271-3 v Brighton & Hove AlbionSouthampton 1-3 Brighton & Hove Albion | Premier League |
| 13 | Sat 7 Jan 2023 | 272-1 v Crystal PalaceCrystal Palace 1-2 Southampton | Emirates FA Cup Third Round |
| 14 | Wed 11 Jan 2023 | 27 2-0 v Manchester CitySouthampton 2-0 Manchester City | Carabao Cup Quarter Final |
| 15 | Sat 14 Jan 2023 | 27 2-1 v EvertonEverton 1-2 Southampton | Premier League |
| 16 | Sat 21 Jan 2023 | 270-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 17 | Tue 24 Jan 2023 | 270-1 v Newcastle UnitedSouthampton 0-1 Newcastle United | Carabao Cup Semi Final |
| 18 | Sat 28 Jan 2023 | 27 2-1 v BlackpoolSouthampton 2-1 Blackpool | Emirates FA Cup Fourth Round |
| 19 | Tue 31 Jan 2023 | 271-2 v Newcastle UnitedNewcastle United 2-1 Southampton | Carabao Cup Semi Final |
| 20 | Sat 4 Feb 2023 | 270-3 v BrentfordBrentford 3-0 Southampton | Premier League |
| 21 | Sat 18 Feb 2023 | 271-0 v ChelseaChelsea 0-1 Southampton | Premier League |
| 22 | Sat 25 Feb 2023 | 27 0-1 v Leeds UnitedLeeds United 1-0 Southampton | Premier League |
| 23 | Wed 15 Mar 2023 | 270-2 v BrentfordSouthampton 0-2 Brentford | Premier League |
| 24 | Sat 8 Apr 2023 | 271-4 v Manchester CitySouthampton 1-4 Manchester City | Premier League |
| 25 | Fri 21 Apr 2023 | 27 3-3 v ArsenalArsenal 3-3 Southampton | Premier League |
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