| 1 | Sat 13 Aug 2022 | 372-2 v Leeds UnitedSouthampton 2-2 Leeds United | Premier League |
| 2 | Sat 20 Aug 2022 | 372-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 3 | Sat 27 Aug 2022 | 370-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 4 | Tue 30 Aug 2022 | 372-1 v ChelseaSouthampton 2-1 Chelsea | Premier League |
| 5 | Sat 3 Sep 2022 | 37 0-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Southampton | Premier League |
| 6 | Fri 16 Sep 2022 | 370-1 v Aston VillaAston Villa 1-0 Southampton | Premier League |
| 7 | Sat 1 Oct 2022 | 371-2 v EvertonSouthampton 1-2 Everton | Premier League |
| 8 | Sat 8 Oct 2022 | 370-4 v Manchester CityManchester City 4-0 Southampton | Premier League |
| 9 | Sun 16 Oct 2022 | 371-1 v West Ham UnitedSouthampton 1-1 West Ham United | Premier League |
| 10 | Sun 6 Nov 2022 | 371-4 v Newcastle UnitedSouthampton 1-4 Newcastle United | Premier League |
| 11 | Sat 12 Nov 2022 | 371-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 12 | Tue 20 Dec 2022 | 372-1 v Lincoln CitySouthampton 2-1 Lincoln City | Carabao Cup Fourth Round |
| 13 | Sat 31 Dec 2022 | 371-2 v FulhamFulham 2-1 Southampton | Premier League |
| 14 | Wed 4 Jan 2023 | 370-1 v Nottingham ForestSouthampton 0-1 Nottingham Forest | Premier League |
| 15 | Sat 28 Jan 2023 | 372-1 v BlackpoolSouthampton 2-1 Blackpool | Emirates FA Cup Fourth Round |
| 16 | Sat 18 Feb 2023 | 37 1-0 v ChelseaChelsea 0-1 Southampton | Premier League |
| 17 | Sat 25 Feb 2023 | 37 0-1 v Leeds UnitedLeeds United 1-0 Southampton | Premier League |
| 18 | Sat 4 Mar 2023 | 371-0 v Leicester CitySouthampton 1-0 Leicester City | Premier League |
| 19 | Sun 12 Mar 2023 | 370-0 v Manchester UnitedManchester United 0-0 Southampton | Premier League |
| 20 | Wed 15 Mar 2023 | 370-2 v BrentfordSouthampton 0-2 Brentford | Premier League |
| 21 | Sat 18 Mar 2023 | 373-3 v Tottenham HotspurSouthampton 3-3 Tottenham Hotspur | Premier League |
| 22 | Sat 8 Apr 2023 | 371-4 v Manchester CitySouthampton 1-4 Manchester City | Premier League |
| 23 | Sat 15 Apr 2023 | 37 0-2 v Crystal PalaceSouthampton 0-2 Crystal Palace | Premier League |
| 24 | Fri 21 Apr 2023 | 373-3 v ArsenalArsenal 3-3 Southampton | Premier League |
| 25 | Sun 30 Apr 2023 | 371-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 26 | Mon 8 May 2023 | 373-4 v Nottingham ForestNottingham Forest 4-3 Southampton | Premier League |
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