| 1 | Sat 3 Sep 2022 | 30-1 v Wolverhampton WanderersWolverhampton Wanderers 1-0 Southampton | Premier League |
| 2 | Sat 1 Oct 2022 | 3 1-2 v EvertonSouthampton 1-2 Everton | Premier League |
| 3 | Sun 16 Oct 2022 | 31-1 v West Ham UnitedSouthampton 1-1 West Ham United | Premier League |
| 4 | Wed 19 Oct 2022 | 3 1-0 v AFC BournemouthAFC Bournemouth 0-1 Southampton | Premier League |
| 5 | Sat 29 Oct 2022 | 30-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 6 | Sun 6 Nov 2022 | 31-4 v Newcastle UnitedSouthampton 1-4 Newcastle United | Premier League |
| 7 | Wed 9 Nov 2022 | 31-1 v Sheffield WednesdaySouthampton 1-1 Sheffield Wednesday | Carabao Cup Third Round |
| 8 | Sat 12 Nov 2022 | 31-3 v LiverpoolLiverpool 3-1 Southampton | Premier League |
| 9 | Tue 20 Dec 2022 | 32-1 v Lincoln CitySouthampton 2-1 Lincoln City | Carabao Cup Fourth Round |
| 10 | Mon 26 Dec 2022 | 31-3 v Brighton & Hove AlbionSouthampton 1-3 Brighton & Hove Albion | Premier League |
| 11 | Sat 31 Dec 2022 | 31-2 v FulhamFulham 2-1 Southampton | Premier League |
| 12 | Sat 7 Jan 2023 | 32-1 v Crystal PalaceCrystal Palace 1-2 Southampton | Emirates FA Cup Third Round |
| 13 | Sat 14 Jan 2023 | 32-1 v EvertonEverton 1-2 Southampton | Premier League |
| 14 | Sat 28 Jan 2023 | 32-1 v BlackpoolSouthampton 2-1 Blackpool | Emirates FA Cup Fourth Round |
| 15 | Sat 11 Feb 2023 | 3 1-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 16 | Sat 18 Feb 2023 | 31-0 v ChelseaChelsea 0-1 Southampton | Premier League |
| 17 | Sat 25 Feb 2023 | 30-1 v Leeds UnitedLeeds United 1-0 Southampton | Premier League |
| 18 | Sat 4 Mar 2023 | 31-0 v Leicester CitySouthampton 1-0 Leicester City | Premier League |
| 19 | Sat 18 Mar 2023 | 33-3 v Tottenham HotspurSouthampton 3-3 Tottenham Hotspur | Premier League |
| 20 | Sun 2 Apr 2023 | 30-1 v West Ham UnitedWest Ham United 1-0 Southampton | Premier League |
| 21 | Sat 8 Apr 2023 | 31-4 v Manchester CitySouthampton 1-4 Manchester City | Premier League |
| 22 | Sat 15 Apr 2023 | 30-2 v Crystal PalaceSouthampton 0-2 Crystal Palace | Premier League |
| 23 | Thu 27 Apr 2023 | 30-1 v AFC BournemouthSouthampton 0-1 AFC Bournemouth | Premier League |
| 24 | Sun 30 Apr 2023 | 31-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 25 | Mon 8 May 2023 | 33-4 v Nottingham ForestNottingham Forest 4-3 Southampton | Premier League |
| 26 | Sat 13 May 2023 | 30-2 v FulhamSouthampton 0-2 Fulham | Premier League |
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