| 1 | Sun 22 Aug 2021 | 351-1 v Manchester UnitedSouthampton 1-1 Manchester United | Premier League |
| 2 | Wed 25 Aug 2021 | 358-0 v Newport CountyNewport County 0-8 Southampton | Carabao Cup Second Round |
| 3 | Sat 18 Sep 2021 | 350-0 v Manchester CityManchester City 0-0 Southampton | Premier League |
| 4 | Tue 21 Sep 2021 | 352-2 v Sheffield UnitedSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 5 | Sun 26 Sep 2021 | 350-1 v Wolverhampton WanderersSouthampton 0-1 Wolverhampton Wanderers | Premier League |
| 6 | Sat 2 Oct 2021 | 351-3 v ChelseaChelsea 3-1 Southampton | Premier League |
| 7 | Sat 16 Oct 2021 | 35 1-0 v Leeds UnitedSouthampton 1-0 Leeds United | Premier League |
| 8 | Sat 23 Oct 2021 | 352-2 v BurnleySouthampton 2-2 Burnley | Premier League |
| 9 | Sat 30 Oct 2021 | 351-0 v WatfordWatford 0-1 Southampton | Premier League |
| 10 | Fri 5 Nov 2021 | 351-0 v Aston VillaSouthampton 1-0 Aston Villa | Premier League |
| 11 | Sat 20 Nov 2021 | 35 1-2 v Norwich CityNorwich City 2-1 Southampton | Premier League |
| 12 | Sat 27 Nov 2021 | 35 0-4 v LiverpoolLiverpool 4-0 Southampton | Premier League |
| 13 | Wed 1 Dec 2021 | 352-2 v Leicester CitySouthampton 2-2 Leicester City | Premier League |
| 14 | Sat 11 Dec 2021 | 350-3 v ArsenalArsenal 3-0 Southampton | Premier League |
| 15 | Sun 26 Dec 2021 | 35 3-2 v West Ham UnitedWest Ham United 2-3 Southampton | Premier League |
| 16 | Tue 28 Dec 2021 | 351-1 v Tottenham HotspurSouthampton 1-1 Tottenham Hotspur | Premier League |
| 17 | Sat 8 Jan 2022 | 353-2 v Swansea CitySwansea City 2-3 Southampton | Emirates FA Cup Third Round |
| 18 | Tue 11 Jan 2022 | 354-1 v BrentfordSouthampton 4-1 Brentford | Premier League |
| 19 | Sat 15 Jan 2022 | 351-3 v Wolverhampton WanderersWolverhampton Wanderers 3-1 Southampton | Premier League |
| 20 | Sat 22 Jan 2022 | 35 1-1 v Manchester CitySouthampton 1-1 Manchester City | Premier League |
| 21 | Wed 9 Feb 2022 | 353-2 v Tottenham HotspurTottenham Hotspur 2-3 Southampton | Premier League |
| 22 | Sat 12 Feb 2022 | 351-1 v Manchester UnitedManchester United 1-1 Southampton | Premier League |
| 23 | Sat 19 Feb 2022 | 352-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 24 | Fri 25 Feb 2022 | 352-0 v Norwich CitySouthampton 2-0 Norwich City | Premier League |
| 25 | Sat 5 Mar 2022 | 350-4 v Aston VillaAston Villa 4-0 Southampton | Premier League |
| 26 | Thu 10 Mar 2022 | 35 1-2 v Newcastle UnitedSouthampton 1-2 Newcastle United | Premier League |
| 27 | Sun 13 Mar 2022 | 35 1-2 v WatfordSouthampton 1-2 Watford | Premier League |
| 28 | Sat 2 Apr 2022 | 351-1 v Leeds UnitedLeeds United 1-1 Southampton | Premier League |
| 29 | Sat 9 Apr 2022 | 35 0-6 v ChelseaSouthampton 0-6 Chelsea | Premier League |
| 30 | Sat 16 Apr 2022 | 351-0 v ArsenalSouthampton 1-0 Arsenal | Premier League |
| 31 | Thu 21 Apr 2022 | 35 0-2 v BurnleyBurnley 2-0 Southampton | Premier League |
| 32 | Sun 24 Apr 2022 | 352-2 v Brighton & Hove AlbionBrighton & Hove Albion 2-2 Southampton | Premier League |
| 33 | Sat 30 Apr 2022 | 35 1-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 34 | Sat 7 May 2022 | 350-3 v BrentfordBrentford 3-0 Southampton | Premier League |
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