| 1 | Sat 12 Sep 2020 | 30-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 2 | Wed 16 Sep 2020 | 30-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 3 | Sun 20 Sep 2020 | 3 2-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 4 | Sat 26 Sep 2020 | 31-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 5 | Sun 4 Oct 2020 | 32-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 6 | Sat 17 Oct 2020 | 33-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 7 | Sun 25 Oct 2020 | 32-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 8 | Sun 1 Nov 2020 | 34-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 9 | Mon 23 Nov 2020 | 31-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 10 | Sun 29 Nov 2020 | 32-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 11 | Mon 7 Dec 2020 | 32-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 12 | Sun 13 Dec 2020 | 33-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 13 | Wed 16 Dec 2020 | 3 1-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 14 | Sat 19 Dec 2020 | 30-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 15 | Sat 26 Dec 2020 | 30-0 v FulhamFulham 0-0 Southampton | Premier League |
| 16 | Tue 29 Dec 2020 | 3 0-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 17 | Mon 4 Jan 2021 | 3 1-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 18 | Sat 16 Jan 2021 | 3 0-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 19 | Sat 23 Jan 2021 | 3 1-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 20 | Sat 30 Jan 2021 | 30-1 v Aston VillaSouthampton 0-1 Aston Villa | Premier League |
| 21 | Tue 2 Feb 2021 | 30-9 v Manchester UnitedManchester United 9-0 Southampton | Premier League |
| 22 | Sat 6 Feb 2021 | 32-3 v Newcastle UnitedNewcastle United 3-2 Southampton | Premier League |
| 23 | Thu 11 Feb 2021 | 32-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 24 | Sun 14 Feb 2021 | 31-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 25 | Sat 20 Feb 2021 | 31-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 26 | Tue 23 Feb 2021 | 30-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 27 | Mon 1 Mar 2021 | 30-1 v EvertonEverton 1-0 Southampton | Premier League |
| 28 | Sat 6 Mar 2021 | 32-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 29 | Wed 10 Mar 2021 | 32-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 30 | Sun 14 Mar 2021 | 31-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 31 | Sat 20 Mar 2021 | 33-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 32 | Sun 4 Apr 2021 | 33-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 33 | Mon 12 Apr 2021 | 30-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 34 | Sun 18 Apr 2021 | 30-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
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