| 1 | Sat 12 Sep 2020 | 2 0-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 2 | Wed 16 Sep 2020 | 20-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 3 | Sun 20 Sep 2020 | 22-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 4 | Sat 26 Sep 2020 | 21-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 5 | Sun 4 Oct 2020 | 2 2-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 6 | Sat 17 Oct 2020 | 23-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 7 | Sun 25 Oct 2020 | 2 2-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 8 | Sun 1 Nov 2020 | 24-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 9 | Fri 6 Nov 2020 | 22-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 10 | Mon 23 Nov 2020 | 21-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 11 | Sun 29 Nov 2020 | 22-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 12 | Mon 7 Dec 2020 | 22-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 13 | Sun 13 Dec 2020 | 23-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 14 | Wed 16 Dec 2020 | 21-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 15 | Sat 19 Dec 2020 | 20-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 16 | Sat 26 Dec 2020 | 20-0 v FulhamFulham 0-0 Southampton | Premier League |
| 17 | Tue 29 Dec 2020 | 2 0-0 v West Ham UnitedSouthampton 0-0 West Ham United | Premier League |
| 18 | Mon 4 Jan 2021 | 21-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 19 | Sat 16 Jan 2021 | 20-2 v Leicester CityLeicester City 2-0 Southampton | Premier League |
| 20 | Sat 23 Jan 2021 | 21-0 v ArsenalSouthampton 1-0 Arsenal | Emirates FA Cup Fourth Round |
| 21 | Thu 11 Feb 2021 | 2 2-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 22 | Sun 14 Feb 2021 | 21-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 23 | Sat 6 Mar 2021 | 22-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 24 | Sun 14 Mar 2021 | 21-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 25 | Sat 20 Mar 2021 | 23-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 26 | Sun 4 Apr 2021 | 23-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 27 | Mon 12 Apr 2021 | 20-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 28 | Sun 18 Apr 2021 | 20-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 29 | Wed 21 Apr 2021 | 21-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 30 | Fri 30 Apr 2021 | 21-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 31 | Sat 8 May 2021 | 20-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 32 | Tue 11 May 2021 | 23-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 33 | Sat 15 May 2021 | 23-1 v FulhamSouthampton 3-1 Fulham | Premier League |
| 34 | Tue 18 May 2021 | 20-2 v Leeds UnitedSouthampton 0-2 Leeds United | Premier League |
| 35 | Sun 23 May 2021 | 20-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
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