| 1 | Sat 18 Aug 2018 | 71-2 v EvertonEverton 2-1 Southampton | Premier League |
| 2 | Sat 25 Aug 2018 | 71-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 3 | Sat 1 Sep 2018 | 72-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 4 | Mon 17 Sep 2018 | 72-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 5 | Sat 22 Sep 2018 | 70-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 6 | Sun 7 Oct 2018 | 70-3 v ChelseaSouthampton 0-3 Chelsea | Premier League |
| 7 | Sat 20 Oct 2018 | 70-0 v AFC BournemouthAFC Bournemouth 0-0 Southampton | Premier League |
| 8 | Sat 27 Oct 2018 | 70-0 v Newcastle UnitedSouthampton 0-0 Newcastle United | Premier League |
| 9 | Sun 4 Nov 2018 | 71-6 v Manchester CityManchester City 6-1 Southampton | Premier League |
| 10 | Sun 16 Dec 2018 | 7 3-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 11 | Thu 27 Dec 2018 | 71-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 12 | Sun 30 Dec 2018 | 71-3 v Manchester CitySouthampton 1-3 Manchester City | Premier League |
| 13 | Wed 2 Jan 2019 | 70-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 14 | Sat 5 Jan 2019 | 72-2 v Derby CountyDerby County 2-2 Southampton | Emirates FA Cup Third Round |
| 15 | Sat 12 Jan 2019 | 72-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 16 | Wed 16 Jan 2019 | 72-2 v Derby CountySouthampton 2-2 Derby County | Emirates FA Cup Third Round Replay |
| 17 | Sat 19 Jan 2019 | 7 2-1 v EvertonSouthampton 2-1 Everton | Premier League |
| 18 | Sat 2 Feb 2019 | 71-1 v BurnleyBurnley 1-1 Southampton | Premier League |
| 19 | Sat 9 Feb 2019 | 71-2 v Cardiff CitySouthampton 1-2 Cardiff City | Premier League |
| 20 | Wed 27 Feb 2019 | 72-0 v FulhamSouthampton 2-0 Fulham | Premier League |
| 21 | Sat 9 Mar 2019 | 72-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur | Premier League |
| 22 | Fri 5 Apr 2019 | 71-3 v LiverpoolSouthampton 1-3 Liverpool | Premier League |
| 23 | Sat 13 Apr 2019 | 73-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers | Premier League |
| 24 | Sat 20 Apr 2019 | 71-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 25 | Tue 23 Apr 2019 | 71-1 v WatfordWatford 1-1 Southampton | Premier League |
| 26 | Sat 27 Apr 2019 | 7 3-3 v AFC BournemouthSouthampton 3-3 AFC Bournemouth | Premier League |
| 27 | Sat 4 May 2019 | 70-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
| 28 | Sun 12 May 2019 | 71-1 v Huddersfield TownSouthampton 1-1 Huddersfield Town | Premier League |
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