| 1 | Tue 28 Aug 2018 | 31-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Southampton | Carabao Cup Second Round |
| 2 | Tue 2 Oct 2018 | 31-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 3 | Sun 7 Oct 2018 | 30-3 v ChelseaSouthampton 0-3 Chelsea | Premier League |
| 4 | Sat 10 Nov 2018 | 31-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 5 | Sat 24 Nov 2018 | 32-3 v FulhamFulham 3-2 Southampton | Premier League |
| 6 | Tue 27 Nov 2018 | 30-0 v Leicester CityLeicester City 0-0 Southampton | Carabao Cup Fourth Round |
| 7 | Sat 1 Dec 2018 | 32-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 8 | Wed 5 Dec 2018 | 31-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 9 | Sun 16 Dec 2018 | 33-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 10 | Sat 22 Dec 2018 | 33-1 v Huddersfield TownHuddersfield Town 1-3 Southampton | Premier League |
| 11 | Thu 27 Dec 2018 | 31-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 12 | Wed 2 Jan 2019 | 30-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 13 | Wed 27 Feb 2019 | 32-0 v FulhamSouthampton 2-0 Fulham | Premier League |
| 14 | Sat 2 Mar 2019 | 32-3 v Manchester UnitedManchester United 3-2 Southampton | Premier League |
| 15 | Sat 9 Mar 2019 | 32-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur | Premier League |
| 16 | Sat 30 Mar 2019 | 31-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Southampton | Premier League |
| 17 | Fri 5 Apr 2019 | 31-3 v LiverpoolSouthampton 1-3 Liverpool | Premier League |
| 18 | Sat 13 Apr 2019 | 33-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers | Premier League |
| 19 | Sat 20 Apr 2019 | 31-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 20 | Tue 23 Apr 2019 | 31-1 v WatfordWatford 1-1 Southampton | Premier League |
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