| 1 | Sat 4 Aug 2018 | 40-3 v Borussia MönchengladbachSouthampton 0-3 Borussia Mönchengladbach | Friendly |
| 2 | Sun 12 Aug 2018 | 40-0 v BurnleySouthampton 0-0 Burnley | Premier League |
| 3 | Sat 25 Aug 2018 | 41-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 4 | Sat 1 Sep 2018 | 4 2-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 5 | Mon 17 Sep 2018 | 42-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 6 | Sat 22 Sep 2018 | 40-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 7 | Sat 29 Sep 2018 | 40-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 8 | Tue 27 Nov 2018 | 40-0 v Leicester CityLeicester City 0-0 Southampton | Carabao Cup Fourth Round |
| 9 | Sat 1 Dec 2018 | 4 2-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 10 | Sat 8 Dec 2018 | 40-1 v Cardiff CityCardiff City 1-0 Southampton | Premier League |
| 11 | Sun 16 Dec 2018 | 43-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 12 | Sat 22 Dec 2018 | 43-1 v Huddersfield TownHuddersfield Town 1-3 Southampton | Premier League |
| 13 | Thu 27 Dec 2018 | 41-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 14 | Wed 2 Jan 2019 | 40-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 15 | Sat 5 Jan 2019 | 42-2 v Derby CountyDerby County 2-2 Southampton | Emirates FA Cup Third Round |
| 16 | Sat 12 Jan 2019 | 42-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 17 | Wed 16 Jan 2019 | 42-2 v Derby CountySouthampton 2-2 Derby County | Emirates FA Cup Third Round Replay |
| 18 | Sat 19 Jan 2019 | 42-1 v EvertonSouthampton 2-1 Everton | Premier League |
| 19 | Wed 30 Jan 2019 | 41-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 20 | Sat 2 Feb 2019 | 41-1 v BurnleyBurnley 1-1 Southampton | Premier League |
| 21 | Sat 9 Feb 2019 | 41-2 v Cardiff CitySouthampton 1-2 Cardiff City | Premier League |
| 22 | Sun 24 Feb 2019 | 40-2 v ArsenalArsenal 2-0 Southampton | Premier League |
| 23 | Wed 27 Feb 2019 | 42-0 v FulhamSouthampton 2-0 Fulham | Premier League |
| 24 | Sat 2 Mar 2019 | 42-3 v Manchester UnitedManchester United 3-2 Southampton | Premier League |
| 25 | Sat 9 Mar 2019 | 42-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur | Premier League |
| 26 | Fri 5 Apr 2019 | 41-3 v LiverpoolSouthampton 1-3 Liverpool | Premier League |
| 27 | Sat 13 Apr 2019 | 43-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers | Premier League |
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