| 1 | Sun 12 Aug 2018 | 20-0 v BurnleySouthampton 0-0 Burnley | Premier League |
| 2 | Sat 18 Aug 2018 | 2 1-2 v EvertonEverton 2-1 Southampton | Premier League |
| 3 | Sat 25 Aug 2018 | 21-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 4 | Sat 1 Sep 2018 | 22-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 5 | Mon 17 Sep 2018 | 2 2-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 6 | Sat 22 Sep 2018 | 20-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 7 | Sat 29 Sep 2018 | 20-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 8 | Tue 2 Oct 2018 | 21-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 9 | Sun 7 Oct 2018 | 2 0-3 v ChelseaSouthampton 0-3 Chelsea | Premier League |
| 10 | Sat 20 Oct 2018 | 20-0 v AFC BournemouthAFC Bournemouth 0-0 Southampton | Premier League |
| 11 | Sat 27 Oct 2018 | 20-0 v Newcastle UnitedSouthampton 0-0 Newcastle United | Premier League |
| 12 | Sun 4 Nov 2018 | 21-6 v Manchester CityManchester City 6-1 Southampton | Premier League |
| 13 | Sat 10 Nov 2018 | 2 1-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 14 | Sat 24 Nov 2018 | 22-3 v FulhamFulham 3-2 Southampton | Premier League |
| 15 | Tue 27 Nov 2018 | 20-0 v Leicester CityLeicester City 0-0 Southampton | Carabao Cup Fourth Round |
| 16 | Sat 1 Dec 2018 | 22-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 17 | Wed 5 Dec 2018 | 21-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 18 | Wed 2 Jan 2019 | 20-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 19 | Sat 5 Jan 2019 | 22-2 v Derby CountyDerby County 2-2 Southampton | Emirates FA Cup Third Round |
| 20 | Sat 12 Jan 2019 | 22-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 21 | Wed 16 Jan 2019 | 2 2-2 v Derby CountySouthampton 2-2 Derby County | Emirates FA Cup Third Round Replay |
| 22 | Sat 19 Jan 2019 | 22-1 v EvertonSouthampton 2-1 Everton | Premier League |
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