| 1 | Sat 29 Jul 2017 | 33-0 v Saint-EtienneSaint-Etienne 0-3 Southampton | Friendly |
| 2 | Sat 5 Aug 2017 | 32-0 v SevillaSouthampton 2-0 Sevilla | Friendly |
| 3 | Sat 12 Aug 2017 | 30-0 v Swansea CitySouthampton 0-0 Swansea City | Premier League |
| 4 | Sat 19 Aug 2017 | 33-2 v West Ham UnitedSouthampton 3-2 West Ham United | Premier League |
| 5 | Wed 23 Aug 2017 | 30-2 v Wolverhampton WanderersSouthampton 0-2 Wolverhampton Wanderers | Carabao Cup Second Round |
| 6 | Sat 26 Aug 2017 | 30-0 v Huddersfield TownHuddersfield Town 0-0 Southampton | Premier League |
| 7 | Sat 16 Sep 2017 | 31-0 v Crystal PalaceCrystal Palace 0-1 Southampton | Premier League |
| 8 | Sat 23 Sep 2017 | 30-1 v Manchester UnitedSouthampton 0-1 Manchester United | Premier League |
| 9 | Sat 30 Sep 2017 | 31-2 v Stoke CityStoke City 2-1 Southampton | Premier League |
| 10 | Sun 15 Oct 2017 | 32-2 v Newcastle UnitedSouthampton 2-2 Newcastle United | Premier League |
| 11 | Sat 21 Oct 2017 | 31-0 v West Bromwich AlbionSouthampton 1-0 West Bromwich Albion | Premier League |
| 12 | Sat 4 Nov 2017 | 30-1 v BurnleySouthampton 0-1 Burnley | Premier League |
| 13 | Sun 26 Nov 2017 | 34-1 v EvertonSouthampton 4-1 Everton | Premier League |
| 14 | Wed 29 Nov 2017 | 31-2 v Manchester CityManchester City 2-1 Southampton | Premier League |
| 15 | Sun 10 Dec 2017 | 31-1 v ArsenalSouthampton 1-1 Arsenal | Premier League |
| 16 | Wed 13 Dec 2017 | 31-4 v Leicester CitySouthampton 1-4 Leicester City | Premier League |
| 17 | Sat 16 Dec 2017 | 3 0-1 v ChelseaChelsea 1-0 Southampton | Premier League |
| 18 | Sat 23 Dec 2017 | 31-1 v Huddersfield TownSouthampton 1-1 Huddersfield Town | Premier League |
| 19 | Tue 26 Dec 2017 | 32-5 v Tottenham HotspurTottenham Hotspur 5-2 Southampton | Premier League |
| 20 | Sat 30 Dec 2017 | 30-0 v Manchester UnitedManchester United 0-0 Southampton | Premier League |
| 21 | Tue 2 Jan 2018 | 31-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Premier League |
| 22 | Sat 6 Jan 2018 | 31-0 v FulhamFulham 0-1 Southampton | Emirates FA Cup Third Round |
| 23 | Sun 8 Apr 2018 | 32-3 v ArsenalArsenal 3-2 Southampton | Premier League |
| 24 | Sat 14 Apr 2018 | 32-3 v ChelseaSouthampton 2-3 Chelsea | Premier League |
| 25 | Thu 19 Apr 2018 | 30-0 v Leicester CityLeicester City 0-0 Southampton | Premier League |
| 26 | Sun 22 Apr 2018 | 3 0-2 v ChelseaChelsea 2-0 Southampton | Emirates FA Cup Semi Final |
| 27 | Sat 28 Apr 2018 | 32-1 v AFC BournemouthSouthampton 2-1 AFC Bournemouth | Premier League |
| 28 | Sat 5 May 2018 | 3 1-1 v EvertonEverton 1-1 Southampton | Premier League |
| 29 | Sun 13 May 2018 | 30-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
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