| 1 | Sat 13 Aug 2016 | 81-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 2 | Fri 19 Aug 2016 | 80-2 v Manchester UnitedManchester United 2-0 Southampton | Premier League |
| 3 | Sat 27 Aug 2016 | 81-1 v SunderlandSouthampton 1-1 Sunderland | Premier League |
| 4 | Sat 10 Sep 2016 | 81-2 v ArsenalArsenal 2-1 Southampton | Premier League |
| 5 | Thu 15 Sep 2016 | 83-0 v Sparta PragueSouthampton 3-0 Sparta Prague | Europa League Group K |
| 6 | Sun 18 Sep 2016 | 81-0 v Swansea CitySouthampton 1-0 Swansea City | Premier League |
| 7 | Sun 25 Sep 2016 | 83-0 v West Ham UnitedWest Ham United 0-3 Southampton | Premier League |
| 8 | Sun 2 Oct 2016 | 80-0 v Leicester CityLeicester City 0-0 Southampton | Premier League |
| 9 | Sun 16 Oct 2016 | 83-1 v BurnleySouthampton 3-1 Burnley | Premier League |
| 10 | Thu 20 Oct 2016 | 80-1 v Inter MilanInter Milan 1-0 Southampton | Europa League Group K |
| 11 | Sun 23 Oct 2016 | 81-1 v Manchester CityManchester City 1-1 Southampton | Premier League |
| 12 | Sun 30 Oct 2016 | 80-2 v ChelseaSouthampton 0-2 Chelsea | Premier League |
| 13 | Thu 3 Nov 2016 | 82-1 v Inter MilanSouthampton 2-1 Inter Milan | Europa League Group K |
| 14 | Sun 6 Nov 2016 | 81-2 v Hull CityHull City 2-1 Southampton | Premier League |
| 15 | Sat 19 Nov 2016 | 80-0 v LiverpoolSouthampton 0-0 Liverpool | Premier League |
| 16 | Wed 30 Nov 2016 | 82-0 v ArsenalArsenal 0-2 Southampton | EFL Cup Quarter Final |
| 17 | Thu 8 Dec 2016 | 81-1 v Hapoel Be-er ShevaSouthampton 1-1 Hapoel Be-er Sheva | Europa League Group K |
| 18 | Sun 11 Dec 2016 | 81-0 v MiddlesbroughSouthampton 1-0 Middlesbrough | Premier League |
| 19 | Wed 14 Dec 2016 | 80-0 v Stoke CityStoke City 0-0 Southampton | Premier League |
| 20 | Sun 18 Dec 2016 | 83-1 v AFC BournemouthAFC Bournemouth 1-3 Southampton | Premier League |
| 21 | Wed 28 Dec 2016 | 81-4 v Tottenham HotspurSouthampton 1-4 Tottenham Hotspur | Premier League |
| 22 | Sat 31 Dec 2016 | 81-2 v West Bromwich AlbionSouthampton 1-2 West Bromwich Albion | Premier League |
| 23 | Wed 11 Jan 2017 | 81-0 v LiverpoolSouthampton 1-0 Liverpool | EFL Cup Semi Final |
| 24 | Wed 25 Jan 2017 | 81-0 v LiverpoolLiverpool 0-1 Southampton | EFL Cup Semi Final |
| 25 | Tue 31 Jan 2017 | 81-2 v Swansea CitySwansea City 2-1 Southampton | Premier League |
| 26 | Sat 4 Feb 2017 | 81-3 v West Ham UnitedSouthampton 1-3 West Ham United | Premier League |
| 27 | Sat 11 Feb 2017 | 84-0 v SunderlandSunderland 0-4 Southampton | Premier League |
| 28 | Sun 26 Feb 2017 | 82-3 v Manchester UnitedManchester United 3-2 Southampton | EFL Cup Final |
| 29 | Sat 4 Mar 2017 | 84-3 v WatfordWatford 3-4 Southampton | Premier League |
| 30 | Sun 19 Mar 2017 | 81-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 31 | Sat 1 Apr 2017 | 80-0 v AFC BournemouthSouthampton 0-0 AFC Bournemouth | Premier League |
| 32 | Wed 5 Apr 2017 | 83-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 33 | Sat 15 Apr 2017 | 80-3 v Manchester CitySouthampton 0-3 Manchester City | Premier League |
| 34 | Tue 25 Apr 2017 | 142-4 v ChelseaChelsea 4-2 Southampton | Premier League |
| 35 | Sat 29 Apr 2017 | 80-0 v Hull CitySouthampton 0-0 Hull City | Premier League |
| 36 | Sun 7 May 2017 | 80-0 v LiverpoolLiverpool 0-0 Southampton | Premier League |
| 37 | Wed 10 May 2017 | 80-2 v ArsenalSouthampton 0-2 Arsenal | Premier League |
| 38 | Sat 13 May 2017 | 82-1 v MiddlesbroughMiddlesbrough 1-2 Southampton | Premier League |
| 39 | Wed 17 May 2017 | 80-0 v Manchester UnitedSouthampton 0-0 Manchester United | Premier League |
| 40 | Sun 21 May 2017 | 80-1 v Stoke CitySouthampton 0-1 Stoke City | Premier League |
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