| 1 | Sat 30 Jul 2016 | 31-0 v GroningenGroningen 0-1 Southampton | Friendly |
| 2 | Sat 30 Jul 2016 | 31-0 v GroningenGroningen 0-1 Southampton | Friendly |
| 3 | Sat 13 Aug 2016 | 31-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 4 | Thu 15 Sep 2016 | 33-0 v Sparta PragueSouthampton 3-0 Sparta Prague | Europa League Group K |
| 5 | Wed 21 Sep 2016 | 32-0 v Crystal PalaceSouthampton 2-0 Crystal Palace | EFL Cup Third Round |
| 6 | Thu 29 Sep 2016 | 30-0 v Hapoel Be-er ShevaHapoel Be-er Sheva 0-0 Southampton | Europa League Group K |
| 7 | Thu 20 Oct 2016 | 30-1 v Inter MilanInter Milan 1-0 Southampton | Europa League Group K |
| 8 | Wed 26 Oct 2016 | 31-0 v SunderlandSouthampton 1-0 Sunderland | EFL Cup Fourth Round |
| 9 | Thu 3 Nov 2016 | 32-1 v Inter MilanSouthampton 2-1 Inter Milan | Europa League Group K |
| 10 | Sun 6 Nov 2016 | 31-2 v Hull CityHull City 2-1 Southampton | Premier League |
| 11 | Thu 24 Nov 2016 | 30-1 v Sparta PragueSparta Prague 1-0 Southampton | Europa League Group K |
| 12 | Wed 30 Nov 2016 | 32-0 v ArsenalArsenal 0-2 Southampton | EFL Cup Quarter Final |
| 13 | Thu 8 Dec 2016 | 31-1 v Hapoel Be-er ShevaSouthampton 1-1 Hapoel Be-er Sheva | Europa League Group K |
| 14 | Sun 18 Dec 2016 | 33-1 v AFC BournemouthAFC Bournemouth 1-3 Southampton | Premier League |
| 15 | Sat 31 Dec 2016 | 31-2 v West Bromwich AlbionSouthampton 1-2 West Bromwich Albion | Premier League |
| 16 | Mon 2 Jan 2017 | 30-3 v EvertonEverton 3-0 Southampton | Premier League |
| 17 | Sat 7 Jan 2017 | 32-2 v Norwich CityNorwich City 2-2 Southampton | Emirates FA Cup Third Round |
| 18 | Wed 11 Jan 2017 | 31-0 v LiverpoolSouthampton 1-0 Liverpool | EFL Cup Semi Final |
| 19 | Sat 14 Jan 2017 | 30-1 v BurnleyBurnley 1-0 Southampton | Premier League |
| 20 | Wed 18 Jan 2017 | 31-0 v Norwich CitySouthampton 1-0 Norwich City | Emirates FA Cup Third Round Replay |
| 21 | Sun 22 Jan 2017 | 33-0 v Leicester CitySouthampton 3-0 Leicester City | Premier League |
| 22 | Wed 25 Jan 2017 | 31-0 v LiverpoolLiverpool 0-1 Southampton | EFL Cup Semi Final |
| 23 | Tue 31 Jan 2017 | 31-2 v Swansea CitySwansea City 2-1 Southampton | Premier League |
| 24 | Sat 4 Feb 2017 | 31-3 v West Ham UnitedSouthampton 1-3 West Ham United | Premier League |
| 25 | Sat 11 Feb 2017 | 34-0 v SunderlandSunderland 0-4 Southampton | Premier League |
| 26 | Sun 26 Feb 2017 | 32-3 v Manchester UnitedManchester United 3-2 Southampton | EFL Cup Final |
| 27 | Sat 4 Mar 2017 | 34-3 v WatfordWatford 3-4 Southampton | Premier League |
| 28 | Sun 19 Mar 2017 | 31-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 29 | Sat 1 Apr 2017 | 30-0 v AFC BournemouthSouthampton 0-0 AFC Bournemouth | Premier League |
| 30 | Wed 5 Apr 2017 | 33-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 31 | Sat 8 Apr 2017 | 31-0 v West Bromwich AlbionWest Bromwich Albion 0-1 Southampton | Premier League |
| 32 | Sat 15 Apr 2017 | 30-3 v Manchester CitySouthampton 0-3 Manchester City | Premier League |
| 33 | Tue 25 Apr 2017 | 32-4 v ChelseaChelsea 4-2 Southampton | Premier League |
| 34 | Sat 29 Apr 2017 | 30-0 v Hull CitySouthampton 0-0 Hull City | Premier League |
| 35 | Sun 7 May 2017 | 30-0 v LiverpoolLiverpool 0-0 Southampton | Premier League |
| 36 | Wed 10 May 2017 | 30-2 v ArsenalSouthampton 0-2 Arsenal | Premier League |
| 37 | Sat 13 May 2017 | 32-1 v MiddlesbroughMiddlesbrough 1-2 Southampton | Premier League |
| 38 | Wed 17 May 2017 | 30-0 v Manchester UnitedSouthampton 0-0 Manchester United | Premier League |
| 39 | Sun 21 May 2017 | 30-1 v Stoke CitySouthampton 0-1 Stoke City | Premier League |
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