| 1 | Fri 19 Aug 2016 | 60-2 v Manchester UnitedManchester United 2-0 Southampton | Premier League |
| 2 | Sat 27 Aug 2016 | 61-1 v SunderlandSouthampton 1-1 Sunderland | Premier League |
| 3 | Sat 10 Sep 2016 | 61-2 v ArsenalArsenal 2-1 Southampton | Premier League |
| 4 | Sun 18 Sep 2016 | 61-0 v Swansea CitySouthampton 1-0 Swansea City | Premier League |
| 5 | Wed 21 Sep 2016 | 62-0 v Crystal PalaceSouthampton 2-0 Crystal Palace | EFL Cup Third Round |
| 6 | Sun 25 Sep 2016 | 63-0 v West Ham UnitedWest Ham United 0-3 Southampton | Premier League |
| 7 | Sun 2 Oct 2016 | 60-0 v Leicester CityLeicester City 0-0 Southampton | Premier League |
| 8 | Sun 16 Oct 2016 | 63-1 v BurnleySouthampton 3-1 Burnley | Premier League |
| 9 | Sun 23 Oct 2016 | 61-1 v Manchester CityManchester City 1-1 Southampton | Premier League |
| 10 | Wed 26 Oct 2016 | 61-0 v SunderlandSouthampton 1-0 Sunderland | EFL Cup Fourth Round |
| 11 | Sun 30 Oct 2016 | 60-2 v ChelseaSouthampton 0-2 Chelsea | Premier League |
| 12 | Sun 6 Nov 2016 | 61-2 v Hull CityHull City 2-1 Southampton | Premier League |
| 13 | Sat 19 Nov 2016 | 60-0 v LiverpoolSouthampton 0-0 Liverpool | Premier League |
| 14 | Sun 27 Nov 2016 | 61-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 15 | Sat 3 Dec 2016 | 60-3 v Crystal PalaceCrystal Palace 3-0 Southampton | Premier League |
| 16 | Sun 11 Dec 2016 | 61-0 v MiddlesbroughSouthampton 1-0 Middlesbrough | Premier League |
| 17 | Wed 14 Dec 2016 | 60-0 v Stoke CityStoke City 0-0 Southampton | Premier League |
| 18 | Wed 28 Dec 2016 | 61-4 v Tottenham HotspurSouthampton 1-4 Tottenham Hotspur | Premier League |
| 19 | Mon 2 Jan 2017 | 60-3 v EvertonEverton 3-0 Southampton | Premier League |
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