| 1 | Sat 30 Jul 2016 | 41-0 v GroningenGroningen 0-1 Southampton | Friendly |
| 2 | Sat 30 Jul 2016 | 41-0 v GroningenGroningen 0-1 Southampton | Friendly |
| 3 | Fri 19 Aug 2016 | 40-2 v Manchester UnitedManchester United 2-0 Southampton | Premier League |
| 4 | Sat 10 Sep 2016 | 41-2 v ArsenalArsenal 2-1 Southampton | Premier League |
| 5 | Sun 18 Sep 2016 | 41-0 v Swansea CitySouthampton 1-0 Swansea City | Premier League |
| 6 | Wed 21 Sep 2016 | 42-0 v Crystal PalaceSouthampton 2-0 Crystal Palace | EFL Cup Third Round |
| 7 | Thu 29 Sep 2016 | 40-0 v Hapoel Be-er ShevaHapoel Be-er Sheva 0-0 Southampton | Europa League Group K |
| 8 | Sun 16 Oct 2016 | 43-1 v BurnleySouthampton 3-1 Burnley | Premier League |
| 9 | Sun 23 Oct 2016 | 41-1 v Manchester CityManchester City 1-1 Southampton | Premier League |
| 10 | Wed 26 Oct 2016 | 41-0 v SunderlandSouthampton 1-0 Sunderland | EFL Cup Fourth Round |
| 11 | Sun 30 Oct 2016 | 40-2 v ChelseaSouthampton 0-2 Chelsea | Premier League |
| 12 | Sun 6 Nov 2016 | 41-2 v Hull CityHull City 2-1 Southampton | Premier League |
| 13 | Thu 24 Nov 2016 | 40-1 v Sparta PragueSparta Prague 1-0 Southampton | Europa League Group K |
| 14 | Sun 27 Nov 2016 | 41-0 v EvertonSouthampton 1-0 Everton | Premier League |
| 15 | Wed 30 Nov 2016 | 42-0 v ArsenalArsenal 0-2 Southampton | EFL Cup Quarter Final |
| 16 | Sun 11 Dec 2016 | 41-0 v MiddlesbroughSouthampton 1-0 Middlesbrough | Premier League |
| 17 | Sun 18 Dec 2016 | 43-1 v AFC BournemouthAFC Bournemouth 1-3 Southampton | Premier League |
| 18 | Mon 2 Jan 2017 | 40-3 v EvertonEverton 3-0 Southampton | Premier League |
| 19 | Wed 11 Jan 2017 | 41-0 v LiverpoolSouthampton 1-0 Liverpool | EFL Cup Semi Final |
| 20 | Wed 18 Jan 2017 | 41-0 v Norwich CitySouthampton 1-0 Norwich City | Emirates FA Cup Third Round Replay |
| 21 | Sun 22 Jan 2017 | 43-0 v Leicester CitySouthampton 3-0 Leicester City | Premier League |
| 22 | Sat 28 Jan 2017 | 40-5 v ArsenalSouthampton 0-5 Arsenal | Emirates FA Cup Fourth Round |
| 23 | Tue 31 Jan 2017 | 41-2 v Swansea CitySwansea City 2-1 Southampton | Premier League |
| 24 | Sat 4 Mar 2017 | 44-3 v WatfordWatford 3-4 Southampton | Premier League |
| 25 | Sat 8 Apr 2017 | 41-0 v West Bromwich AlbionWest Bromwich Albion 0-1 Southampton | Premier League |
| 26 | Sat 13 May 2017 | 42-1 v MiddlesbroughMiddlesbrough 1-2 Southampton | Premier League |
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