| 1 | Sun 9 Aug 2015 | 32-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Barclays Premier League |
| 2 | Sat 15 Aug 2015 | 30-3 v EvertonSouthampton 0-3 Everton | Barclays Premier League |
| 3 | Thu 20 Aug 2015 | 31-1 v FC MidtjyllandSouthampton 1-1 FC Midtjylland | Europa League |
| 4 | Sun 23 Aug 2015 | 30-0 v WatfordWatford 0-0 Southampton | Barclays Premier League |
| 5 | Thu 27 Aug 2015 | 30-1 v FC MidtjyllandFC Midtjylland 1-0 Southampton | Europa League |
| 6 | Sun 30 Aug 2015 | 33-0 v Norwich CitySouthampton 3-0 Norwich City | Barclays Premier League |
| 7 | Sat 12 Sep 2015 | 30-0 v West Bromwich AlbionWest Bromwich Albion 0-0 Southampton | Barclays Premier League |
| 8 | Sun 20 Sep 2015 | 32-3 v Manchester UnitedSouthampton 2-3 Manchester United | Barclays Premier League |
| 9 | Sat 17 Oct 2015 | 32-2 v Leicester CitySouthampton 2-2 Leicester City | Barclays Premier League |
| 10 | Wed 28 Oct 2015 | 32-1 v Aston VillaSouthampton 2-1 Aston Villa | Capital One Cup Fourth Round |
| 11 | Sun 1 Nov 2015 | 32-0 v AFC BournemouthSouthampton 2-0 AFC Bournemouth | Barclays Premier League |
| 12 | Sat 7 Nov 2015 | 31-0 v SunderlandSunderland 0-1 Southampton | Barclays Premier League |
| 13 | Sat 28 Nov 2015 | 31-3 v Manchester CityManchester City 3-1 Southampton | Barclays Premier League |
| 14 | Sat 12 Dec 2015 | 30-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Barclays Premier League |
| 15 | Mon 28 Dec 2015 | 31-2 v West Ham UnitedWest Ham United 2-1 Southampton | Barclays Premier League |
| 16 | Sat 9 Jan 2016 | 31-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Emirates FA Cup Third Round |
| 17 | Wed 13 Jan 2016 | 32-0 v WatfordSouthampton 2-0 Watford | Barclays Premier League |
| 18 | Sat 6 Feb 2016 | 31-0 v West Ham UnitedSouthampton 1-0 West Ham United | Barclays Premier League |
| 19 | Tue 1 Mar 2016 | 30-2 v AFC BournemouthAFC Bournemouth 2-0 Southampton | Barclays Premier League |
| 20 | Sat 5 Mar 2016 | 31-1 v SunderlandSouthampton 1-1 Sunderland | Barclays Premier League |
| 21 | Sat 16 Apr 2016 | 31-1 v EvertonEverton 1-1 Southampton | Barclays Premier League |
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