| 1 | Sun 9 Aug 2015 | 62-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Barclays Premier League |
| 2 | Sat 15 Aug 2015 | 60-3 v EvertonSouthampton 0-3 Everton | Barclays Premier League |
| 3 | Thu 20 Aug 2015 | 61-1 v FC MidtjyllandSouthampton 1-1 FC Midtjylland | Europa League |
| 4 | Sun 23 Aug 2015 | 60-0 v WatfordWatford 0-0 Southampton | Barclays Premier League |
| 5 | Thu 27 Aug 2015 | 60-1 v FC MidtjyllandFC Midtjylland 1-0 Southampton | Europa League |
| 6 | Sun 30 Aug 2015 | 63-0 v Norwich CitySouthampton 3-0 Norwich City | Barclays Premier League |
| 7 | Sat 12 Sep 2015 | 60-0 v West Bromwich AlbionWest Bromwich Albion 0-0 Southampton | Barclays Premier League |
| 8 | Sun 20 Sep 2015 | 62-3 v Manchester UnitedSouthampton 2-3 Manchester United | Barclays Premier League |
| 9 | Wed 23 Sep 2015 | 66-0 v Milton Keynes DonsMilton Keynes Dons 0-6 Southampton | Capital One Cup Third Round |
| 10 | Sat 26 Sep 2015 | 63-1 v Swansea CitySouthampton 3-1 Swansea City | Barclays Premier League |
| 11 | Sat 3 Oct 2015 | 63-1 v ChelseaChelsea 1-3 Southampton | Barclays Premier League |
| 12 | Sat 17 Oct 2015 | 62-2 v Leicester CitySouthampton 2-2 Leicester City | Barclays Premier League |
| 13 | Sun 25 Oct 2015 | 61-1 v LiverpoolLiverpool 1-1 Southampton | Barclays Premier League |
| 14 | Sun 1 Nov 2015 | 62-0 v AFC BournemouthSouthampton 2-0 AFC Bournemouth | Barclays Premier League |
| 15 | Sat 7 Nov 2015 | 61-0 v SunderlandSunderland 0-1 Southampton | Barclays Premier League |
| 16 | Sat 21 Nov 2015 | 60-1 v Stoke CitySouthampton 0-1 Stoke City | Barclays Premier League |
| 17 | Sat 28 Nov 2015 | 61-3 v Manchester CityManchester City 3-1 Southampton | Barclays Premier League |
| 18 | Sat 5 Dec 2015 | 61-1 v Aston VillaSouthampton 1-1 Aston Villa | Barclays Premier League |
| 19 | Sat 12 Dec 2015 | 60-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Barclays Premier League |
| 20 | Sat 19 Dec 2015 | 60-2 v Tottenham HotspurSouthampton 0-2 Tottenham Hotspur | Barclays Premier League |
| 21 | Sat 26 Dec 2015 | 64-0 v ArsenalSouthampton 4-0 Arsenal | Barclays Premier League |
| 22 | Mon 28 Dec 2015 | 61-2 v West Ham UnitedWest Ham United 2-1 Southampton | Barclays Premier League |
| 23 | Sat 2 Jan 2016 | 60-1 v Norwich CityNorwich City 1-0 Southampton | Barclays Premier League |
| 24 | Sat 9 Jan 2016 | 61-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Emirates FA Cup Third Round |
| 25 | Wed 13 Jan 2016 | 62-0 v WatfordSouthampton 2-0 Watford | Barclays Premier League |
| 26 | Sat 16 Jan 2016 | 63-0 v West Bromwich AlbionSouthampton 3-0 West Bromwich Albion | Barclays Premier League |
| 27 | Sat 23 Jan 2016 | 61-0 v Manchester UnitedManchester United 0-1 Southampton | Barclays Premier League |
| 28 | Tue 2 Feb 2016 | 60-0 v ArsenalArsenal 0-0 Southampton | Barclays Premier League |
| 29 | Sat 6 Feb 2016 | 61-0 v West Ham UnitedSouthampton 1-0 West Ham United | Barclays Premier League |
| 30 | Sat 13 Feb 2016 | 61-0 v Swansea CitySwansea City 0-1 Southampton | Barclays Premier League |
| 31 | Sat 27 Feb 2016 | 61-2 v ChelseaSouthampton 1-2 Chelsea | Barclays Premier League |
| 32 | Tue 1 Mar 2016 | 60-2 v AFC BournemouthAFC Bournemouth 2-0 Southampton | Barclays Premier League |
| 33 | Sat 5 Mar 2016 | 171-1 v SunderlandSouthampton 1-1 Sunderland | Barclays Premier League |
| 34 | Sun 20 Mar 2016 | 63-2 v LiverpoolSouthampton 3-2 Liverpool | Barclays Premier League |
| 35 | Sun 3 Apr 2016 | 60-1 v Leicester CityLeicester City 1-0 Southampton | Barclays Premier League |
| 36 | Sat 9 Apr 2016 | 63-1 v Newcastle UnitedSouthampton 3-1 Newcastle United | Barclays Premier League |
| 37 | Sat 16 Apr 2016 | 61-1 v EvertonEverton 1-1 Southampton | Barclays Premier League |
| 38 | Sat 23 Apr 2016 | 64-2 v Aston VillaAston Villa 2-4 Southampton | Barclays Premier League |
| 39 | Sun 1 May 2016 | 64-2 v Manchester CitySouthampton 4-2 Manchester City | Barclays Premier League |
| 40 | Sun 8 May 2016 | 62-1 v Tottenham HotspurTottenham Hotspur 1-2 Southampton | Barclays Premier League |
| 41 | Sun 15 May 2016 | 64-1 v Crystal PalaceSouthampton 4-1 Crystal Palace | Barclays Premier League |
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