| 1 | Sat 17 Oct 2015 | 42-2 v Leicester CitySouthampton 2-2 Leicester City | Barclays Premier League |
| 2 | Sun 25 Oct 2015 | 41-1 v LiverpoolLiverpool 1-1 Southampton | Barclays Premier League |
| 3 | Sun 1 Nov 2015 | 42-0 v AFC BournemouthSouthampton 2-0 AFC Bournemouth | Barclays Premier League |
| 4 | Sat 7 Nov 2015 | 41-0 v SunderlandSunderland 0-1 Southampton | Barclays Premier League |
| 5 | Sat 21 Nov 2015 | 40-1 v Stoke CitySouthampton 0-1 Stoke City | Barclays Premier League |
| 6 | Wed 2 Dec 2015 | 41-6 v LiverpoolSouthampton 1-6 Liverpool | Capital One Cup Quarter Final |
| 7 | Sat 19 Dec 2015 | 40-2 v Tottenham HotspurSouthampton 0-2 Tottenham Hotspur | Barclays Premier League |
| 8 | Sat 26 Dec 2015 | 44-0 v ArsenalSouthampton 4-0 Arsenal | Barclays Premier League |
| 9 | Sat 2 Jan 2016 | 120-1 v Norwich CityNorwich City 1-0 Southampton | Barclays Premier League |
| 10 | Sat 9 Jan 2016 | 41-2 v Crystal PalaceSouthampton 1-2 Crystal Palace | Emirates FA Cup Third Round |
| 11 | Wed 13 Jan 2016 | 42-0 v WatfordSouthampton 2-0 Watford | Barclays Premier League |
| 12 | Sat 23 Jan 2016 | 41-0 v Manchester UnitedManchester United 0-1 Southampton | Barclays Premier League |
| 13 | Sat 6 Feb 2016 | 41-0 v West Ham UnitedSouthampton 1-0 West Ham United | Barclays Premier League |
| 14 | Sat 13 Feb 2016 | 41-0 v Swansea CitySwansea City 0-1 Southampton | Barclays Premier League |
| 15 | Sat 27 Feb 2016 | 41-2 v ChelseaSouthampton 1-2 Chelsea | Barclays Premier League |
| 16 | Sat 5 Mar 2016 | 41-1 v SunderlandSouthampton 1-1 Sunderland | Barclays Premier League |
| 17 | Sat 12 Mar 2016 | 42-1 v Stoke CityStoke City 1-2 Southampton | Barclays Premier League |
| 18 | Sun 20 Mar 2016 | 43-2 v LiverpoolSouthampton 3-2 Liverpool | Barclays Premier League |
| 19 | Sun 3 Apr 2016 | 40-1 v Leicester CityLeicester City 1-0 Southampton | Barclays Premier League |
| 20 | Sat 9 Apr 2016 | 43-1 v Newcastle UnitedSouthampton 3-1 Newcastle United | Barclays Premier League |
| 21 | Sat 16 Apr 2016 | 41-1 v EvertonEverton 1-1 Southampton | Barclays Premier League |
| 22 | Sat 23 Apr 2016 | 44-2 v Aston VillaAston Villa 2-4 Southampton | Barclays Premier League |
| 23 | Sun 1 May 2016 | 44-2 v Manchester CitySouthampton 4-2 Manchester City | Barclays Premier League |
| 24 | Sun 8 May 2016 | 42-1 v Tottenham HotspurTottenham Hotspur 1-2 Southampton | Barclays Premier League |
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