| 1 | Wed 13 Jan 2016 | 442-0 v WatfordSouthampton 2-0 Watford | Barclays Premier League |
| 2 | Sat 16 Jan 2016 | 443-0 v West Bromwich AlbionSouthampton 3-0 West Bromwich Albion | Barclays Premier League |
| 3 | Sat 23 Jan 2016 | 441-0 v Manchester UnitedManchester United 0-1 Southampton | Barclays Premier League |
| 4 | Tue 2 Feb 2016 | 440-0 v ArsenalArsenal 0-0 Southampton | Barclays Premier League |
| 5 | Sat 6 Feb 2016 | 441-0 v West Ham UnitedSouthampton 1-0 West Ham United | Barclays Premier League |
| 6 | Sat 13 Feb 2016 | 441-0 v Swansea CitySwansea City 0-1 Southampton | Barclays Premier League |
| 7 | Sat 27 Feb 2016 | 441-2 v ChelseaSouthampton 1-2 Chelsea | Barclays Premier League |
| 8 | Tue 1 Mar 2016 | 440-2 v AFC BournemouthAFC Bournemouth 2-0 Southampton | Barclays Premier League |
| 9 | Sat 5 Mar 2016 | 441-1 v SunderlandSouthampton 1-1 Sunderland | Barclays Premier League |
| 10 | Sat 12 Mar 2016 | 442-1 v Stoke CityStoke City 1-2 Southampton | Barclays Premier League |
| 11 | Sun 20 Mar 2016 | 443-2 v LiverpoolSouthampton 3-2 Liverpool | Barclays Premier League |
| 12 | Sun 3 Apr 2016 | 440-1 v Leicester CityLeicester City 1-0 Southampton | Barclays Premier League |
| 13 | Sat 9 Apr 2016 | 443-1 v Newcastle UnitedSouthampton 3-1 Newcastle United | Barclays Premier League |
| 14 | Sat 16 Apr 2016 | 441-1 v EvertonEverton 1-1 Southampton | Barclays Premier League |
| 15 | Sat 23 Apr 2016 | 444-2 v Aston VillaAston Villa 2-4 Southampton | Barclays Premier League |
| 16 | Sun 1 May 2016 | 444-2 v Manchester CitySouthampton 4-2 Manchester City | Barclays Premier League |
| 17 | Sun 8 May 2016 | 442-1 v Tottenham HotspurTottenham Hotspur 1-2 Southampton | Barclays Premier League |
| 18 | Sun 15 May 2016 | 444-1 v Crystal PalaceSouthampton 4-1 Crystal Palace | Barclays Premier League |
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