| 1 | Sun 9 Aug 2015 | 22-2 v Newcastle UnitedNewcastle United 2-2 Southampton | Barclays Premier League |
| 2 | Sat 15 Aug 2015 | 20-3 v EvertonSouthampton 0-3 Everton | Barclays Premier League |
| 3 | Sun 23 Aug 2015 | 20-0 v WatfordWatford 0-0 Southampton | Barclays Premier League |
| 4 | Sun 30 Aug 2015 | 23-0 v Norwich CitySouthampton 3-0 Norwich City | Barclays Premier League |
| 5 | Sat 12 Sep 2015 | 20-0 v West Bromwich AlbionWest Bromwich Albion 0-0 Southampton | Barclays Premier League |
| 6 | Wed 23 Sep 2015 | 26-0 v Milton Keynes DonsMilton Keynes Dons 0-6 Southampton | Capital One Cup Third Round |
| 7 | Sat 26 Sep 2015 | 23-1 v Swansea CitySouthampton 3-1 Swansea City | Barclays Premier League |
| 8 | Sat 3 Oct 2015 | 23-1 v ChelseaChelsea 1-3 Southampton | Barclays Premier League |
| 9 | Sat 17 Oct 2015 | 22-2 v Leicester CitySouthampton 2-2 Leicester City | Barclays Premier League |
| 10 | Sun 25 Oct 2015 | 21-1 v LiverpoolLiverpool 1-1 Southampton | Barclays Premier League |
| 11 | Sun 1 Nov 2015 | 22-0 v AFC BournemouthSouthampton 2-0 AFC Bournemouth | Barclays Premier League |
| 12 | Sat 21 Nov 2015 | 20-1 v Stoke CitySouthampton 0-1 Stoke City | Barclays Premier League |
| 13 | Wed 2 Dec 2015 | 21-6 v LiverpoolSouthampton 1-6 Liverpool | Capital One Cup Quarter Final |
| 14 | Sat 5 Dec 2015 | 21-1 v Aston VillaSouthampton 1-1 Aston Villa | Barclays Premier League |
| 15 | Sat 12 Dec 2015 | 20-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Barclays Premier League |
| 16 | Sat 19 Dec 2015 | 20-2 v Tottenham HotspurSouthampton 0-2 Tottenham Hotspur | Barclays Premier League |
| 17 | Wed 13 Jan 2016 | 22-0 v WatfordSouthampton 2-0 Watford | Barclays Premier League |
| 18 | Sat 16 Jan 2016 | 23-0 v West Bromwich AlbionSouthampton 3-0 West Bromwich Albion | Barclays Premier League |
| 19 | Sat 23 Jan 2016 | 21-0 v Manchester UnitedManchester United 0-1 Southampton | Barclays Premier League |
| 20 | Tue 2 Feb 2016 | 20-0 v ArsenalArsenal 0-0 Southampton | Barclays Premier League |
| 21 | Sat 6 Feb 2016 | 21-0 v West Ham UnitedSouthampton 1-0 West Ham United | Barclays Premier League |
| 22 | Sat 13 Feb 2016 | 21-0 v Swansea CitySwansea City 0-1 Southampton | Barclays Premier League |
| 23 | Sat 27 Feb 2016 | 21-2 v ChelseaSouthampton 1-2 Chelsea | Barclays Premier League |
| 24 | Tue 1 Mar 2016 | 20-2 v AFC BournemouthAFC Bournemouth 2-0 Southampton | Barclays Premier League |
| 25 | Sun 3 Apr 2016 | 20-1 v Leicester CityLeicester City 1-0 Southampton | Barclays Premier League |
| 26 | Sat 23 Apr 2016 | 24-2 v Aston VillaAston Villa 2-4 Southampton | Barclays Premier League |
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