| 1 | Sun 19 Aug 2012 | 42-3 v Manchester CityManchester City 3-2 Southampton | Barclays Premier League |
| 2 | Sat 25 Aug 2012 | 40-2 v Wigan AthleticSouthampton 0-2 Wigan Athletic | Barclays Premier League |
| 3 | Sun 2 Sep 2012 | 42-3 v Manchester UnitedSouthampton 2-3 Manchester United | Barclays Premier League |
| 4 | Sat 15 Sep 2012 | 41-6 v ArsenalArsenal 6-1 Southampton | Barclays Premier League |
| 5 | Sat 22 Sep 2012 | 44-1 v Aston VillaSouthampton 4-1 Aston Villa | Barclays Premier League |
| 6 | Sun 7 Oct 2012 | 42-2 v FulhamSouthampton 2-2 Fulham | Barclays Premier League |
| 7 | Sat 20 Oct 2012 | 41-4 v West Ham UnitedWest Ham United 4-1 Southampton | Barclays Premier League |
| 8 | Sun 28 Oct 2012 | 41-2 v Tottenham HotspurSouthampton 1-2 Tottenham Hotspur | Barclays Premier League |
| 9 | Mon 5 Nov 2012 | 40-2 v West Bromwich AlbionWest Bromwich Albion 2-0 Southampton | Barclays Premier League |
| 10 | Sat 10 Nov 2012 | 41-1 v Swansea CitySouthampton 1-1 Swansea City | Barclays Premier League |
| 11 | Sat 17 Nov 2012 | 43-1 v Queens Park RangersQueens Park Rangers 1-3 Southampton | Barclays Premier League |
| 12 | Sun 25 Nov 2012 | 42-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Barclays Premier League |
| 13 | Wed 28 Nov 2012 | 41-1 v Norwich CitySouthampton 1-1 Norwich City | Barclays Premier League |
| 14 | Sat 1 Dec 2012 | 40-1 v LiverpoolLiverpool 1-0 Southampton | Barclays Premier League |
| 15 | Sat 8 Dec 2012 | 41-0 v ReadingSouthampton 1-0 Reading | Barclays Premier League |
| 16 | Sat 22 Dec 2012 | 40-1 v SunderlandSouthampton 0-1 Sunderland | Barclays Premier League |
| 17 | Wed 26 Dec 2012 | 41-1 v FulhamFulham 1-1 Southampton | Barclays Premier League |
| 18 | Sat 29 Dec 2012 | 43-3 v Stoke CityStoke City 3-3 Southampton | Barclays Premier League |
| 19 | Tue 1 Jan 2013 | 41-1 v ArsenalSouthampton 1-1 Arsenal | Barclays Premier League |
| 20 | Sat 5 Jan 2013 | 41-5 v ChelseaSouthampton 1-5 Chelsea | FA Cup with Budweiser Third Round |
| 21 | Sat 12 Jan 2013 | 41-0 v Aston VillaAston Villa 0-1 Southampton | Barclays Premier League |
| 22 | Wed 16 Jan 2013 | 42-2 v ChelseaChelsea 2-2 Southampton | Barclays Premier League |
| 23 | Mon 21 Jan 2013 | 40-0 v EvertonSouthampton 0-0 Everton | Barclays Premier League |
| 24 | Wed 30 Jan 2013 | 41-2 v Manchester UnitedManchester United 2-1 Southampton | Barclays Premier League |
| 25 | Sat 2 Feb 2013 | 42-2 v Wigan AthleticWigan Athletic 2-2 Southampton | Barclays Premier League |
| 26 | Sat 9 Feb 2013 | 43-1 v Manchester CitySouthampton 3-1 Manchester City | Barclays Premier League |
| 27 | Sun 24 Feb 2013 | 42-4 v Newcastle UnitedNewcastle United 4-2 Southampton | Barclays Premier League |
| 28 | Sat 2 Mar 2013 | 41-2 v Queens Park RangersSouthampton 1-2 Queens Park Rangers | Barclays Premier League |
| 29 | Sat 9 Mar 2013 | 40-0 v Norwich CityNorwich City 0-0 Southampton | Barclays Premier League |
| 30 | Sat 16 Mar 2013 | 43-1 v LiverpoolSouthampton 3-1 Liverpool | Barclays Premier League |
| 31 | Sat 30 Mar 2013 | 42-1 v ChelseaSouthampton 2-1 Chelsea | Barclays Premier League |
| 32 | Sat 6 Apr 2013 | 42-0 v ReadingReading 0-2 Southampton | Barclays Premier League |
| 33 | Sat 13 Apr 2013 | 41-1 v West Ham UnitedSouthampton 1-1 West Ham United | Barclays Premier League |
| 34 | Sat 20 Apr 2013 | 40-0 v Swansea CitySwansea City 0-0 Southampton | Barclays Premier League |
| 35 | Sat 27 Apr 2013 | 40-3 v West Bromwich AlbionSouthampton 0-3 West Bromwich Albion | Barclays Premier League |
| 36 | Sun 12 May 2013 | 41-1 v SunderlandSunderland 1-1 Southampton | Barclays Premier League |
| 37 | Sun 19 May 2013 | 41-1 v Stoke CitySouthampton 1-1 Stoke City | Barclays Premier League |
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