| 1 | Sun 19 Aug 2012 | 62-3 v Manchester CityManchester City 3-2 Southampton | Barclays Premier League |
| 2 | Sat 25 Aug 2012 | 60-2 v Wigan AthleticSouthampton 0-2 Wigan Athletic | Barclays Premier League |
| 3 | Sun 2 Sep 2012 | 62-3 v Manchester UnitedSouthampton 2-3 Manchester United | Barclays Premier League |
| 4 | Sat 15 Sep 2012 | 61-6 v ArsenalArsenal 6-1 Southampton | Barclays Premier League |
| 5 | Sat 22 Sep 2012 | 64-1 v Aston VillaSouthampton 4-1 Aston Villa | Barclays Premier League |
| 6 | Sat 29 Sep 2012 | 61-3 v EvertonEverton 3-1 Southampton | Barclays Premier League |
| 7 | Sun 7 Oct 2012 | 62-2 v FulhamSouthampton 2-2 Fulham | Barclays Premier League |
| 8 | Sat 20 Oct 2012 | 61-4 v West Ham UnitedWest Ham United 4-1 Southampton | Barclays Premier League |
| 9 | Sun 28 Oct 2012 | 61-2 v Tottenham HotspurSouthampton 1-2 Tottenham Hotspur | Barclays Premier League |
| 10 | Mon 5 Nov 2012 | 60-2 v West Bromwich AlbionWest Bromwich Albion 2-0 Southampton | Barclays Premier League |
| 11 | Sat 10 Nov 2012 | 61-1 v Swansea CitySouthampton 1-1 Swansea City | Barclays Premier League |
| 12 | Sat 17 Nov 2012 | 63-1 v Queens Park RangersQueens Park Rangers 1-3 Southampton | Barclays Premier League |
| 13 | Sun 25 Nov 2012 | 62-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Barclays Premier League |
| 14 | Wed 28 Nov 2012 | 61-1 v Norwich CitySouthampton 1-1 Norwich City | Barclays Premier League |
| 15 | Sat 1 Dec 2012 | 60-1 v LiverpoolLiverpool 1-0 Southampton | Barclays Premier League |
| 16 | Sat 8 Dec 2012 | 61-0 v ReadingSouthampton 1-0 Reading | Barclays Premier League |
| 17 | Sat 22 Dec 2012 | 60-1 v SunderlandSouthampton 0-1 Sunderland | Barclays Premier League |
| 18 | Wed 26 Dec 2012 | 61-1 v FulhamFulham 1-1 Southampton | Barclays Premier League |
| 19 | Sat 29 Dec 2012 | 63-3 v Stoke CityStoke City 3-3 Southampton | Barclays Premier League |
| 20 | Tue 1 Jan 2013 | 61-1 v ArsenalSouthampton 1-1 Arsenal | Barclays Premier League |
| 21 | Sat 5 Jan 2013 | 61-5 v ChelseaSouthampton 1-5 Chelsea | FA Cup with Budweiser Third Round |
| 22 | Sat 2 Mar 2013 | 61-2 v Queens Park RangersSouthampton 1-2 Queens Park Rangers | Barclays Premier League |
| 23 | Sat 9 Mar 2013 | 60-0 v Norwich CityNorwich City 0-0 Southampton | Barclays Premier League |
| 24 | Sat 16 Mar 2013 | 63-1 v LiverpoolSouthampton 3-1 Liverpool | Barclays Premier League |
| 25 | Sat 27 Apr 2013 | 60-3 v West Bromwich AlbionSouthampton 0-3 West Bromwich Albion | Barclays Premier League |
| 26 | Sat 4 May 2013 | 60-1 v Tottenham HotspurTottenham Hotspur 1-0 Southampton | Barclays Premier League |
| 27 | Sun 12 May 2013 | 61-1 v SunderlandSunderland 1-1 Southampton | Barclays Premier League |
| 28 | Sun 19 May 2013 | 61-1 v Stoke CitySouthampton 1-1 Stoke City | Barclays Premier League |
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