| 1 | Sun 19 Aug 2012 | 52-3 v Manchester CityManchester City 3-2 Southampton | Barclays Premier League |
| 2 | Sat 25 Aug 2012 | 50-2 v Wigan AthleticSouthampton 0-2 Wigan Athletic | Barclays Premier League |
| 3 | Sun 2 Sep 2012 | 52-3 v Manchester UnitedSouthampton 2-3 Manchester United | Barclays Premier League |
| 4 | Sat 15 Sep 2012 | 51-6 v ArsenalArsenal 6-1 Southampton | Barclays Premier League |
| 5 | Tue 25 Sep 2012 | 52-0 v Sheffield WednesdaySouthampton 2-0 Sheffield Wednesday | Capital One Cup Third Round |
| 6 | Sun 7 Oct 2012 | 52-2 v FulhamSouthampton 2-2 Fulham | Barclays Premier League |
| 7 | Sat 20 Oct 2012 | 51-4 v West Ham UnitedWest Ham United 4-1 Southampton | Barclays Premier League |
| 8 | Tue 30 Oct 2012 | 50-3 v Leeds UnitedLeeds United 3-0 Southampton | Capital One Cup Fourth Round |
| 9 | Sun 25 Nov 2012 | 52-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Barclays Premier League |
| 10 | Sat 29 Dec 2012 | 53-3 v Stoke CityStoke City 3-3 Southampton | Barclays Premier League |
| 11 | Sat 5 Jan 2013 | 51-5 v ChelseaSouthampton 1-5 Chelsea | FA Cup with Budweiser Third Round |
| 12 | Sat 12 Jan 2013 | 51-0 v Aston VillaAston Villa 0-1 Southampton | Barclays Premier League |
| 13 | Wed 16 Jan 2013 | 52-2 v ChelseaChelsea 2-2 Southampton | Barclays Premier League |
| 14 | Mon 21 Jan 2013 | 50-0 v EvertonSouthampton 0-0 Everton | Barclays Premier League |
| 15 | Wed 30 Jan 2013 | 51-2 v Manchester UnitedManchester United 2-1 Southampton | Barclays Premier League |
| 16 | Sat 2 Feb 2013 | 52-2 v Wigan AthleticWigan Athletic 2-2 Southampton | Barclays Premier League |
| 17 | Sat 9 Feb 2013 | 53-1 v Manchester CitySouthampton 3-1 Manchester City | Barclays Premier League |
| 18 | Sun 24 Feb 2013 | 52-4 v Newcastle UnitedNewcastle United 4-2 Southampton | Barclays Premier League |
| 19 | Sat 9 Mar 2013 | 50-0 v Norwich CityNorwich City 0-0 Southampton | Barclays Premier League |
| 20 | Sat 16 Mar 2013 | 53-1 v LiverpoolSouthampton 3-1 Liverpool | Barclays Premier League |
| 21 | Sat 30 Mar 2013 | 52-1 v ChelseaSouthampton 2-1 Chelsea | Barclays Premier League |
| 22 | Sat 6 Apr 2013 | 52-0 v ReadingReading 0-2 Southampton | Barclays Premier League |
| 23 | Sat 13 Apr 2013 | 51-1 v West Ham UnitedSouthampton 1-1 West Ham United | Barclays Premier League |
| 24 | Sat 20 Apr 2013 | 50-0 v Swansea CitySwansea City 0-0 Southampton | Barclays Premier League |
| 25 | Sat 27 Apr 2013 | 50-3 v West Bromwich AlbionSouthampton 0-3 West Bromwich Albion | Barclays Premier League |
| 26 | Sat 4 May 2013 | 50-1 v Tottenham HotspurTottenham Hotspur 1-0 Southampton | Barclays Premier League |
| 27 | Sun 12 May 2013 | 51-1 v SunderlandSunderland 1-1 Southampton | Barclays Premier League |
| 28 | Sun 19 May 2013 | 51-1 v Stoke CitySouthampton 1-1 Stoke City | Barclays Premier League |
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