| 1 | Tue 17 Aug 2021 | 221-0 v Fleetwood TownSheffield Wednesday 1-0 Fleetwood Town | Sky Bet League One |
| 2 | Sat 21 Aug 2021 | 222-0 v Rotherham UnitedRotherham United 0-2 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 18 Sep 2021 | 22 1-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 4 | Sat 25 Sep 2021 | 221-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 5 | Tue 28 Sep 2021 | 22 2-1 v Wigan AthleticWigan Athletic 1-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Sat 2 Oct 2021 | 221-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 7 | Tue 5 Oct 2021 | 222-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 8 | Sat 9 Oct 2021 | 221-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 9 | Sat 16 Oct 2021 | 22 2-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 10 | Tue 19 Oct 2021 | 221-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 11 | Sat 30 Oct 2021 | 222-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 12 | Tue 2 Nov 2021 | 223-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 13 | Sun 7 Nov 2021 | 220-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 14 | Sat 13 Nov 2021 | 221-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 15 | Tue 16 Nov 2021 | 220-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 16 | Sat 20 Nov 2021 | 223-2 v Accrington StanleyAccrington Stanley 2-3 Sheffield Wednesday | Sky Bet League One |
| 17 | Tue 23 Nov 2021 | 222-1 v Milton Keynes DonsSheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 18 | Sat 27 Nov 2021 | 222-2 v Wycombe WanderersSheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 19 | Thu 30 Dec 2021 | 220-5 v SunderlandSunderland 5-0 Sheffield Wednesday | Sky Bet League One |
| 20 | Sat 19 Mar 2022 | 22 0-0 v GillinghamGillingham 0-0 Sheffield Wednesday | Sky Bet League One |
| 21 | Sat 16 Apr 2022 | 223-2 v Milton Keynes DonsMilton Keynes Dons 2-3 Sheffield Wednesday | Sky Bet League One |
| 22 | Tue 19 Apr 2022 | 221-0 v Crewe AlexandraSheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 23 | Sat 23 Apr 2022 | 22 0-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 24 | Tue 26 Apr 2022 | 223-2 v Fleetwood TownFleetwood Town 2-3 Sheffield Wednesday | Sky Bet League One |
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