| 1 | Sat 7 Aug 2021 | 80-1 v Birmingham CitySheffield United 0-1 Birmingham City | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 80-0 v Swansea CitySwansea City 0-0 Sheffield United | Sky Bet Championship |
| 3 | Wed 18 Aug 2021 | 80-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Sheffield United | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 81-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 80-0 v Luton TownLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | Tue 14 Sep 2021 | 82-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 7 | Sat 18 Sep 2021 | 83-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 8 | Sun 28 Nov 2021 | 82-0 v Bristol CitySheffield United 2-0 Bristol City | Sky Bet Championship |
| 9 | Mon 20 Dec 2021 | 81-0 v FulhamFulham 0-1 Sheffield United | Sky Bet Championship |
| 10 | Sun 9 Jan 2022 | 80-3 v Wolverhampton WanderersWolverhampton Wanderers 3-0 Sheffield United | Emirates FA Cup Third Round |
| 11 | Sat 15 Jan 2022 | 80-2 v Derby CountyDerby County 2-0 Sheffield United | Sky Bet Championship |
| 12 | Tue 18 Jan 2022 | 82-2 v Preston North EndPreston North End 2-2 Sheffield United | Sky Bet Championship |
| 13 | Sat 22 Jan 2022 | 82-0 v Luton TownSheffield United 2-0 Luton Town | Sky Bet Championship |
| 14 | Fri 4 Feb 2022 | 82-1 v Birmingham CityBirmingham City 1-2 Sheffield United | Sky Bet Championship |
| 15 | Wed 9 Feb 2022 | 82-0 v West Bromwich AlbionSheffield United 2-0 West Bromwich Albion | Sky Bet Championship |
| 16 | Sat 12 Feb 2022 | 8 0-0 v Huddersfield TownHuddersfield Town 0-0 Sheffield United | Sky Bet Championship |
| 17 | Tue 15 Feb 2022 | 80-0 v Hull CitySheffield United 0-0 Hull City | Sky Bet Championship |
| 18 | Sat 19 Feb 2022 | 84-0 v Swansea CitySheffield United 4-0 Swansea City | Sky Bet Championship |
| 19 | Wed 23 Feb 2022 | 8 1-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers | Sky Bet Championship |
| 20 | Sat 26 Feb 2022 | 80-1 v MillwallMillwall 1-0 Sheffield United | Sky Bet Championship |
| 21 | Fri 4 Mar 2022 | 81-1 v Nottingham ForestSheffield United 1-1 Nottingham Forest | Sky Bet Championship |
| 22 | Tue 8 Mar 2022 | 84-1 v MiddlesbroughSheffield United 4-1 Middlesbrough | Sky Bet Championship |
| 23 | Sat 12 Mar 2022 | 81-4 v Coventry CityCoventry City 4-1 Sheffield United | Sky Bet Championship |
| 24 | Wed 16 Mar 2022 | 80-0 v BlackpoolBlackpool 0-0 Sheffield United | Sky Bet Championship |
| 25 | Sat 19 Mar 2022 | 82-0 v BarnsleySheffield United 2-0 Barnsley | Sky Bet Championship |
| 26 | Sat 2 Apr 2022 | 80-1 v Stoke CityStoke City 1-0 Sheffield United | Sky Bet Championship |
| 27 | Tue 5 Apr 2022 | 81-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 28 | Sat 9 Apr 2022 | 80-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 29 | Fri 15 Apr 2022 | 81-2 v ReadingSheffield United 1-2 Reading | Sky Bet Championship |
| 30 | Mon 18 Apr 2022 | 81-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 31 | Sat 23 Apr 2022 | 81-0 v Cardiff CitySheffield United 1-0 Cardiff City | Sky Bet Championship |
| 32 | Fri 29 Apr 2022 | 83-1 v Queens Park RangersQueens Park Rangers 1-3 Sheffield United | Sky Bet Championship |
| 33 | Sat 7 May 2022 | 84-0 v FulhamSheffield United 4-0 Fulham | Sky Bet Championship |
| 34 | Sat 14 May 2022 | 81-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
| 35 | Tue 17 May 2022 | 82-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United | Sky Bet Championship Play-off Semi Final |
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