| 1 | Sat 7 Aug 2021 | 20-1 v Birmingham CitySheffield United 0-1 Birmingham City | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 2 0-0 v Swansea CitySwansea City 0-0 Sheffield United | Sky Bet Championship |
| 3 | Wed 18 Aug 2021 | 20-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Sheffield United | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 21-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 20-0 v Luton TownLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 26-2 v Peterborough UnitedSheffield United 6-2 Peterborough United | Sky Bet Championship |
| 7 | Tue 14 Sep 2021 | 22-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 23-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 9 | Sat 25 Sep 2021 | 21-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 10 | Tue 28 Sep 2021 | 20-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 11 | Sat 2 Oct 2021 | 21-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 12 | Sun 24 Oct 2021 | 23-2 v BarnsleyBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 13 | Sat 30 Oct 2021 | 20-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 14 | Sat 6 Nov 2021 | 21-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 15 | Wed 9 Feb 2022 | 22-0 v West Bromwich AlbionSheffield United 2-0 West Bromwich Albion | Sky Bet Championship |
| 16 | Sat 12 Feb 2022 | 20-0 v Huddersfield TownHuddersfield Town 0-0 Sheffield United | Sky Bet Championship |
| 17 | Tue 15 Feb 2022 | 2 0-0 v Hull CitySheffield United 0-0 Hull City | Sky Bet Championship |
| 18 | Sat 19 Feb 2022 | 2 4-0 v Swansea CitySheffield United 4-0 Swansea City | Sky Bet Championship |
| 19 | Wed 23 Feb 2022 | 21-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers | Sky Bet Championship |
| 20 | Sat 26 Feb 2022 | 2 0-1 v MillwallMillwall 1-0 Sheffield United | Sky Bet Championship |
| 21 | Sat 2 Apr 2022 | 20-1 v Stoke CityStoke City 1-0 Sheffield United | Sky Bet Championship |
| 22 | Tue 5 Apr 2022 | 21-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 23 | Sat 9 Apr 2022 | 20-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 24 | Fri 15 Apr 2022 | 2 1-2 v ReadingSheffield United 1-2 Reading | Sky Bet Championship |
| 25 | Mon 18 Apr 2022 | 2 1-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 26 | Sat 14 May 2022 | 2 1-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
| 27 | Tue 17 May 2022 | 22-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United | Sky Bet Championship Play-off Semi Final |
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