| 1 | Tue 14 Sep 2021 | 21-1 v SV Red Bull SalzburgSevilla 1-1 SV Red Bull Salzburg | UEFA Champions League Group G |
| 2 | Wed 22 Sep 2021 | 2 3-1 v ValenciaSevilla 3-1 Valencia | Spanish La Liga |
| 3 | Sun 3 Oct 2021 | 20-1 v GranadaGranada 1-0 Sevilla | Spanish La Liga |
| 4 | Sat 30 Oct 2021 | 22-0 v OsasunaSevilla 2-0 Osasuna | Spanish La Liga |
| 5 | Tue 2 Nov 2021 | 2 1-2 v LilleSevilla 1-2 Lille | UEFA Champions League Group G |
| 6 | Sun 7 Nov 2021 | 22-0 v Real BetisReal Betis 0-2 Sevilla | Spanish La Liga |
| 7 | Sat 20 Nov 2021 | 22-2 v AlavésSevilla 2-2 Alavés | Spanish La Liga |
| 8 | Tue 23 Nov 2021 | 22-0 v VfL WolfsburgSevilla 2-0 VfL Wolfsburg | UEFA Champions League Group G |
| 9 | Sun 28 Nov 2021 | 2 1-2 v Real MadridReal Madrid 2-1 Sevilla | Spanish La Liga |
| 10 | Sat 4 Dec 2021 | 21-0 v VillarrealSevilla 1-0 Villarreal | Spanish La Liga |
| 11 | Wed 8 Dec 2021 | 20-1 v SV Red Bull SalzburgSV Red Bull Salzburg 1-0 Sevilla | UEFA Champions League Group G |
| 12 | Sat 11 Dec 2021 | 21-0 v Athletic BilbaoAthletic Bilbao 0-1 Sevilla | Spanish La Liga |
| 13 | Sat 18 Dec 2021 | 2 2-1 v Atlético MadridSevilla 2-1 Atlético Madrid | Spanish La Liga |
| 14 | Sun 9 Jan 2022 | 21-0 v GetafeSevilla 1-0 Getafe | Spanish La Liga |
| 15 | Wed 19 Jan 2022 | 2 1-1 v ValenciaValencia 1-1 Sevilla | Spanish La Liga |
| 16 | Sat 22 Jan 2022 | 22-2 v Celta VigoSevilla 2-2 Celta Vigo | Spanish La Liga |
| 17 | Sat 5 Feb 2022 | 20-0 v OsasunaOsasuna 0-0 Sevilla | Spanish La Liga |
| 18 | Thu 24 Feb 2022 | 20-1 v Dinamo ZagrebDinamo Zagreb 1-0 Sevilla | UEFA Europa League Round of 32 |
| 19 | Thu 17 Mar 2022 | 2 0-2 v West Ham UnitedWest Ham United 2-0 Sevilla | UEFA Europa League Round of 16 |
| 20 | Sun 20 Mar 2022 | 20-0 v Real SociedadSevilla 0-0 Real Sociedad | Spanish La Liga |
| 21 | Sun 3 Apr 2022 | 2 0-1 v BarcelonaBarcelona 1-0 Sevilla | Spanish La Liga |
| 22 | Thu 21 Apr 2022 | 2 3-2 v LevanteLevante 2-3 Sevilla | Spanish La Liga |
| 23 | Sun 8 May 2022 | 21-1 v VillarrealVillarreal 1-1 Sevilla | Spanish La Liga |
| 24 | Sun 15 May 2022 | 2 1-1 v Atlético MadridAtlético Madrid 1-1 Sevilla | Spanish La Liga |
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